CDC45 and CAMK1G

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		CDC45	CAMK1G
Description		cell division cycle 45	calcium/calmodulin dependent protein kinase IG
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Pre-replicative Complex Cytoplasm Centrosome DNA Replication Preinitiation Complex Replication Fork Protection Complex	Golgi Membrane Intracellular Plasma Membrane Calcium- And Calmodulin-dependent Protein Kinase Complex Neuron Projection
	Molecular Function	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding
	Biological Process	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of Chromatin Silencing At Telomere Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Replication Preinitiation Complex Assembly	Protein Phosphorylation
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs			5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872)	Age-related cognitive decline (visuospatial skill) (slope of z-scores) ( 30954325) Amyotrophic lateral sclerosis ( 23624525) Obesity (extreme) ( 21935397)
Interacting Genes		23 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CSK GINS4 LCK MAPK3 MCM10 MCM2 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 TOPBP1 TRAPPC3 UBC	2 interacting genes: CDC45 PJA1
Entrez ID		8318	57172
HPRD ID		09145	10807
Ensembl ID		ENSG00000093009	ENSG00000008118
Uniprot IDs		O75419	Q96NX5
PDB IDs		5DGO	2JAM
Enriched GO Terms of Interacting Partners?
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