KCTD5 and NEK6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		KCTD5	NEK6
Description		potassium channel tetramerization domain containing 5	NIMA related kinase 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cul3-RING Ubiquitin Ligase Complex	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Microtubule Nuclear Speck Protein-containing Complex Centriolar Satellite Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding Cullin Family Protein Binding	Magnesium Ion Binding Transcription Corepressor Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding
	Biological Process	Viral Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Homooligomerization	Protein Phosphorylation Apoptotic Process Chromosome Segregation Mitotic Nuclear Envelope Disassembly Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Spindle Assembly Cell Division Regulation Of Cellular Senescence
Pathways			Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Cognitive performance ( 20125193) Free thyroxine concentration ( 30367059) Heel bone mineral density ( 30598549) Medication use (thyroid preparations) ( 31015401) Mercury levels ( 26025379) Neurociticism ( 29500382) Pulse pressure ( 30224653) Vitiligo ( 27723757)
Interacting Genes		8 interacting genes: CD1A CUL3 EP300 GIT2 GORASP2 NEK6 NXF1 PRKAB2	43 interacting genes: ANKRA2 ARHGAP33 ARRB1 ATF4 CCDC85B CDC42 CDK7 CIR1 ERCC6L2 HSD17B14 IHO1 IKZF1 IKZF3 INCA1 KCTD5 KRT31 KRT40 LNX1 LZTS2 NECAB2 NEK9 PAK6 PHF1 PIN1 PRAM1 PRDX3 PTN PTPRD RBBP6 RPS6KB1 RPS7 SGK1 SMAD4 SMURF2 TASOR2 TCF4 TGFBR1 TLE5 TNK2 TRIM23 TRIM27 TRIP4 XIAP
Entrez ID		54442	10783
HPRD ID		13768	05348
Ensembl ID		ENSG00000167977	ENSG00000119408
Uniprot IDs		Q9NXV2	A0A024R8A6 Q9HC98
PDB IDs		3DRX 3DRY 3DRZ
Enriched GO Terms of Interacting Partners?
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