NEK6 and PRDX3

Number of citations of the paper that reports this interaction (PubMedID 20873783)
18

Data Source:
BioGRID (two hybrid, pull down)

		NEK6	PRDX3
Description		NIMA related kinase 6	peroxiredoxin 3
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Microtubule Nuclear Speck Protein-containing Complex Centriolar Satellite Intracellular Membrane-bounded Organelle	Cell Cytoplasm Mitochondrion Mitochondrial Matrix Early Endosome Cytosol Protein-containing Complex
	Molecular Function	Magnesium Ion Binding Transcription Corepressor Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding	Protein Binding Protein C-terminus Binding Thioredoxin Peroxidase Activity Alkyl Hydroperoxide Reductase Activity Kinase Binding Protein Kinase Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Protein Phosphorylation Apoptotic Process Chromosome Segregation Mitotic Nuclear Envelope Disassembly Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Spindle Assembly Cell Division Regulation Of Cellular Senescence	Maternal Placenta Development Apoptotic Process Response To Oxidative Stress Mitochondrion Organization Positive Regulation Of Cell Proliferation Peptidyl-cysteine Oxidation Myeloid Cell Differentiation Response To Lipopolysaccharide Negative Regulation Of Kinase Activity Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Redox Homeostasis Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Mitochondrial Membrane Potential Cellular Oxidant Detoxification
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation	Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Cognitive performance ( 20125193) Free thyroxine concentration ( 30367059) Heel bone mineral density ( 30598549) Medication use (thyroid preparations) ( 31015401) Mercury levels ( 26025379) Neurociticism ( 29500382) Pulse pressure ( 30224653) Vitiligo ( 27723757)	Alcoholic chronic pancreatitis ( 28754779)
Interacting Genes		43 interacting genes: ANKRA2 ARHGAP33 ARRB1 ATF4 CCDC85B CDC42 CDK7 CIR1 ERCC6L2 HSD17B14 IHO1 IKZF1 IKZF3 INCA1 KCTD5 KRT31 KRT40 LNX1 LZTS2 NECAB2 NEK9 PAK6 PHF1 PIN1 PRAM1 PRDX3 PTN PTPRD RBBP6 RPS6KB1 RPS7 SGK1 SMAD4 SMURF2 TASOR2 TCF4 TGFBR1 TLE5 TNK2 TRIM23 TRIM27 TRIP4 XIAP	12 interacting genes: CUL4B FANCC GORASP2 HNRNPD MAGEA11 MAP3K13 NEK6 NR3C1 PRDX4 RPS6KC1 SUMO4 TNFRSF1A
Entrez ID		10783	10935
HPRD ID		05348	05305
Ensembl ID		ENSG00000119408	ENSG00000165672
Uniprot IDs		A0A024R8A6 Q9HC98	A0A384MTR2 P30048
PDB IDs			5JCG 5UCX
Enriched GO Terms of Interacting Partners?
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