NEK6 and ARHGAP33

Number of citations of the paper that reports this interaction (PubMedID 20873783)
18

Data Source:
BioGRID (two hybrid, pull down)

		NEK6	ARHGAP33
Description		NIMA related kinase 6	Rho GTPase activating protein 33
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Microtubule Nuclear Speck Protein-containing Complex Centriolar Satellite Intracellular Membrane-bounded Organelle	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex Dendritic Spine
	Molecular Function	Magnesium Ion Binding Transcription Corepressor Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding	GTPase Activator Activity Protein Binding Protein Kinase Binding Phosphatidylinositol Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Chromosome Segregation Mitotic Nuclear Envelope Disassembly Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Spindle Assembly Cell Division Regulation Of Cellular Senescence	Small GTPase Mediated Signal Transduction Response To Toxic Substance Protein Transport Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Dendritic Spine Morphogenesis
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation	Rho GTPase cycle
Drugs
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Cognitive performance ( 20125193) Free thyroxine concentration ( 30367059) Heel bone mineral density ( 30598549) Medication use (thyroid preparations) ( 31015401) Mercury levels ( 26025379) Neurociticism ( 29500382) Pulse pressure ( 30224653) Vitiligo ( 27723757)	Umami taste perception in obesity with metabolic syndrome ( 31005965) Urinary albumin-to-creatinine ratio ( 26631737)
Interacting Genes		43 interacting genes: ANKRA2 ARHGAP33 ARRB1 ATF4 CCDC85B CDC42 CDK7 CIR1 ERCC6L2 HSD17B14 IHO1 IKZF1 IKZF3 INCA1 KCTD5 KRT31 KRT40 LNX1 LZTS2 NECAB2 NEK9 PAK6 PHF1 PIN1 PRAM1 PRDX3 PTN PTPRD RBBP6 RPS6KB1 RPS7 SGK1 SMAD4 SMURF2 TASOR2 TCF4 TGFBR1 TLE5 TNK2 TRIM23 TRIM27 TRIP4 XIAP	3 interacting genes: FYN NEK6 RAC1
Entrez ID		10783	115703
HPRD ID		05348	15415
Ensembl ID		ENSG00000119408	ENSG00000004777
Uniprot IDs		A0A024R8A6 Q9HC98	A1A5D2 O14559
PDB IDs
Enriched GO Terms of Interacting Partners?
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