DDX11 and PKP2

		DDX11	PKP2
Description		DEAD/H-box helicase 11	plakophilin 2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Spindle Pole Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Midbody Mitotic Cohesin Complex Ctf18 RFC-like Complex Extracellular Exosome	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Integral Component Of Membrane Cell Junction Desmosome Messenger Ribonucleoprotein Complex
	Molecular Function	DNA Binding DNA Helicase Activity Chromatin Binding DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity RNA-dependent ATPase Activity Triplex DNA Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding G-quadruplex DNA Binding	Protein Kinase C Binding Protein Binding Sodium Channel Regulator Activity Intermediate Filament Binding Ion Channel Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	DNA Repair Cellular Response To DNA Damage Stimulus Sister Chromatid Cohesion Multicellular Organism Development Viral Process Replication Fork Processing Positive Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Protein Binding DNA Duplex Unwinding Establishment Of Sister Chromatid Cohesion Positive Regulation Of Chromatin Binding IRE1-mediated Unfolded Protein Response G-quadruplex DNA Unwinding Positive Regulation Of Sister Chromatid Cohesion Cellular Response To Hydroxyurea Cellular Response To Cisplatin Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Cellular Response To Bleomycin Nucleolar Chromatin Organization Positive Regulation Of Double-strand Break Repair	Desmosome Assembly Desmosome Organization Cell-cell Junction Assembly Heart Development Positive Regulation Of Sodium Ion Transport Keratinization Intermediate Filament Bundle Assembly Maintenance Of Animal Organ Identity Ventricular Cardiac Muscle Tissue Morphogenesis Cornification Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Cell-cell Signaling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		XBP1(S) activates chaperone genes	Keratinization Formation of the cornified envelope
Drugs
Diseases		Warsaw breakage syndrome	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS			Atrial fibrillation ( 30061737 29892015) Blood protein levels ( 30072576) Body mass index (change over time) in lung cancer ( 28044437) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965) Periodontal disease related phenotype (PCT5) ( 26962152) Prevalent atrial fibrillation ( 28416818)
Interacting Genes		3 interacting genes: KAT7 PFN2 PKP2	26 interacting genes: AKAP9 CASK CTNNB1 DDX11 DMRTB1 DSC1 DSC2 DSG1 DSG2 DSP GTF2IRD1 HSPB2 ITPR2 JUP KDM5A KLC4 KRT18 KRT5 MARK3 MTUS2 NDEL1 POLR3A RBM5 SINHCAF SMAD9 YWHAG
Entrez ID		1663	5318
HPRD ID		03095	04177
Ensembl ID		ENSG00000013573	ENSG00000057294
Uniprot IDs		Q2NKM7 Q96FC9	Q99959
PDB IDs			3TT9
Enriched GO Terms of Interacting Partners?
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