LSM8 and IFNLR1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
HPRD (two hybrid)

		LSM8	IFNLR1
Description		LSM8 homolog, U6 small nuclear RNA associated	interferon lambda receptor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm U6 SnRNP U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Lsm2-8 Complex	Plasma Membrane Integral Component Of Membrane Interleukin-28 Receptor Complex
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding	Cytokine Receptor Activity Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Metabolic Process	Mucosal Immune Response Negative Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Response To Type III Interferon Regulation Of Defense Response To Virus By Host Defense Response To Virus
Pathways		mRNA Splicing - Major Pathway	Other interleukin signaling Interleukin-20 family signaling
Drugs
Diseases
GWAS		Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Glaucoma (primary open-angle) ( 29891935) Intraocular pressure ( 29617998) Plasma anti-thyroid peroxidase levels ( 29678681) Positive urgency ( 30718321) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Triglyceride levels ( 30108155)	Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory skin disease ( 25574825) Molybdenum levels ( 26025379) Psoriasis vulgaris ( 26626624)
Interacting Genes		49 interacting genes: ARNT BCKDK COL23A1 DBF4 DCP1A DCP1B DPAGT1 ECHDC2 EFTUD2 EXOSC10 EXOSC6 FERMT3 GMPPA GTF2I HSPA9 IFNLR1 IGHMBP2 ISOC2 ITSN2 KCTD3 LSM2 LSM3 LSM5 LSM6 LSM7 MAPK8IP2 MGA MINDY1 MPRIP MRPL48 MTHFR NAGK NME4 PDCD2 PGD PHF11 RBM5 RPL24 RSC1A1 RSL24D1 SEPTIN10 SEPTIN5 SMU1 SNRNP200 SNRPB SNRPD1 TALDO1 THUMPD3 UPF1	3 interacting genes: IFNL1 IFNL2 LSM8
Entrez ID		51691	163702
HPRD ID		06288	09589
Ensembl ID		ENSG00000128534	ENSG00000185436
Uniprot IDs		A4D0W0 O95777	Q8IU57
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9	3OG4 3OG6 5IXD 5IXI 5L04 5T5W
Enriched GO Terms of Interacting Partners?
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