IFNLR1 and IFNL1

Number of citations of the paper that reports this interaction (PubMedID 12469119)
445

Data Source:
HPRD (in vivo)

		IFNLR1	IFNL1
Description		interferon lambda receptor 1	interferon lambda 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Interleukin-28 Receptor Complex	Extracellular Region Extracellular Space Interleukin-28 Receptor Complex
	Molecular Function	Cytokine Receptor Activity Protein Binding	Signaling Receptor Binding Cytokine Activity Interleukin-28 Receptor Binding
	Biological Process	Mucosal Immune Response Negative Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Response To Type III Interferon Regulation Of Defense Response To Virus By Host Defense Response To Virus	Negative Regulation Of Type 2 Immune Response JAK-STAT Cascade Negative Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-5 Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Immune Response Defense Response To Virus
Pathways		Other interleukin signaling Interleukin-20 family signaling	Other interleukin signaling Interleukin-20 family signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory skin disease ( 25574825) Molybdenum levels ( 26025379) Psoriasis vulgaris ( 26626624)
Interacting Genes		3 interacting genes: IFNL1 IFNL2 LSM8	1 interacting genes: IFNLR1
Entrez ID		163702	282618
HPRD ID		09589	09588
Ensembl ID		ENSG00000185436	ENSG00000182393
Uniprot IDs		Q8IU57	Q8IU54
PDB IDs		3OG4 3OG6 5IXD 5IXI 5L04 5T5W	3OG4 3OG6
Enriched GO Terms of Interacting Partners?
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