LSM8 and IGHMBP2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
HPRD (two hybrid)

		LSM8	IGHMBP2
Description		LSM8 homolog, U6 small nuclear RNA associated	immunoglobulin mu DNA binding protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm U6 SnRNP U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Lsm2-8 Complex	Nucleus Nucleoplasm Cytoplasm Membrane Axon Growth Cone Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding	TRNA Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding RNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Transcription Factor Binding RNA-dependent ATPase Activity Zinc Ion Binding 5'-3' RNA Helicase Activity Identical Protein Binding Ribosome Binding 5'-3' DNA Helicase Activity
	Biological Process	MRNA Splicing, Via Spliceosome RNA Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Repair DNA Recombination Translation DNA Duplex Unwinding
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases			Distal hereditary motor neuropathies (dHMN)
GWAS		Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Glaucoma (primary open-angle) ( 29891935) Intraocular pressure ( 29617998) Plasma anti-thyroid peroxidase levels ( 29678681) Positive urgency ( 30718321) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Triglyceride levels ( 30108155)	Heel bone mineral density ( 28869591)
Interacting Genes		49 interacting genes: ARNT BCKDK COL23A1 DBF4 DCP1A DCP1B DPAGT1 ECHDC2 EFTUD2 EXOSC10 EXOSC6 FERMT3 GMPPA GTF2I HSPA9 IFNLR1 IGHMBP2 ISOC2 ITSN2 KCTD3 LSM2 LSM3 LSM5 LSM6 LSM7 MAPK8IP2 MGA MINDY1 MPRIP MRPL48 MTHFR NAGK NME4 PDCD2 PGD PHF11 RBM5 RPL24 RSC1A1 RSL24D1 SEPTIN10 SEPTIN5 SMU1 SNRNP200 SNRPB SNRPD1 TALDO1 THUMPD3 UPF1	1 interacting genes: LSM8
Entrez ID		51691	3508
HPRD ID		06288	02736
Ensembl ID		ENSG00000128534	ENSG00000132740
Uniprot IDs		A4D0W0 O95777	P38935
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9	1MSZ 2LRR 4B3F 4B3G
Enriched GO Terms of Interacting Partners?
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