ABI1 and SOS2

Number of citations of the paper that reports this interaction (PubMedID 11003655)
21

Data Source:
HPRD (in vivo)

		ABI1	SOS2
Description		abl interactor 1	SOS Ras/Rho guanine nucleotide exchange factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Intracellular Nucleus Endoplasmic Reticulum Cytosol Cytoskeleton Plasma Membrane Postsynaptic Density Aggresome Lamellipodium Cell Junction Growth Cone SCAR Complex Filopodium Tip Extracellular Exosome	Nucleosome Cytosol
	Molecular Function	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Protein Tyrosine Kinase Activator Activity Cadherin Binding	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Somitogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Actin Polymerization Or Depolymerization Negative Regulation Of Cell Proliferation Viral Process Peptidyl-tyrosine Phosphorylation Megakaryocyte Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Dendrite Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Lamellipodium Morphogenesis	G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Activation of RAC1 Interleukin-15 signaling
Drugs
Diseases
GWAS			Birth weight ( 31043758) Erythema nodosum in inflammatory bowel disease ( 24487271) Estimated glomerular filtration rate ( 31015462) Intraocular pressure ( 29617998 29785010 31959993 30054594) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Periodontal disease-related phenotype (Socransky) ( 24347629) Pulse pressure ( 30578418)
Interacting Genes		29 interacting genes: ABL1 APBB1 CACNA1A CUL2 CYFIP2 ENAH EPS8 EPS8L1 EVL GAS7 HSPA8 MINK1 NCK1 NCK2 NCKAP1 NEB NIN PAK2 PCM1 PRPF40A SOS1 SOS2 SPTA1 SPTAN1 SRRM1 TCERG1 VASP WASF1 WASF2	16 interacting genes: ABI1 ABL1 BIN1 CD2AP CRKL EGFR GRAP2 GRB2 HRAS ITSN2 PACSIN3 PLCG1 SH3D19 SHC1 SNX18 SNX9
Entrez ID		10006	6655
HPRD ID		04336	03149
Ensembl ID		ENSG00000136754	ENSG00000100485
Uniprot IDs		A0A0A0MRT6 B6VEX3 B6VEX4 B6VEX5 Q8IZP0	Q07890
PDB IDs			6EIE
Enriched GO Terms of Interacting Partners?
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