PAX5 and KPNA1

Number of citations of the paper that reports this interaction (PubMedID 10748034)
11

Data Source:
HPRD (two hybrid, in vitro)

		PAX5	KPNA1
Description		paired box 5	karyopherin subunit alpha 1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Fibrillar Center Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Dendrite Host Cell Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Humoral Immune Response Multicellular Organism Development Spermatogenesis Aging Animal Organ Morphogenesis Lateral Ventricle Development Cerebral Cortex Development Adult Behavior Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Histone H3-K9 Methylation	Regulation Of DNA Recombination Apoptotic DNA Fragmentation NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Process Intracellular Transport Of Virus Postsynapse To Nucleus Signaling Pathway
Pathways		RUNX1 regulates transcription of genes involved in BCR signaling	ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Integration of provirus Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Vpr-mediated nuclear import of PICs Inhibition of nitric oxide production
Drugs
Diseases		Lymphoplasmacytic lymphoma
GWAS		Alzheimer's disease ( 30636644) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Coronary artery disease in type 1 diabetes ( 29695241) HIV-1 susceptibility ( 25786224) Intelligence ( 22449649) Major depressive disorder ( 27479909) Moderate to vigorous physical activity levels ( 29899525) Morning person ( 30696823) Obesity-related traits ( 22013104)	Calcium levels ( 20705733) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		16 interacting genes: CREBBP DAXX EBF1 EP300 ETS1 ID2 ID3 KPNA1 KPNA2 MAPK1 MYB RB1 RUNX1 TBP TLE4 UBE3A	39 interacting genes: ANP32A ANP32B ARNT BCAR3 CDKN1B CLK4 CRADD CSE1L ELAVL1 EPAS1 FOSL1 GOPC GTF2IRD1 H2BC21 H3-4 HDAC6 HIF1A IL1RAP KPNB1 LEF1 LMO4 MDM2 NOSIP NUP54 NUP62 ORC4 PAX5 PKM RAG1 RANBP2 RUNX1T1 SENP2 SKP2 SRP19 STAT1 STAT3 TAF9 UBR5 USP1
Entrez ID		5079	3836
HPRD ID		01334	02819
Ensembl ID		ENSG00000196092	ENSG00000114030
Uniprot IDs		C0KTE5 C0KTF5 E7EQT0 E7ERK2 E7ERW5 E7ES87 Q02548	B3KXZ2 P52294
PDB IDs		1K78 1MDM	2JDQ 3TJ3 4B18
Enriched GO Terms of Interacting Partners?
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