PAX5 and EBF1

Number of citations of the paper that reports this interaction (PubMedID 14594818)
9

Data Source:
HPRD (in vitro)

		PAX5	EBF1
Description		paired box 5	EBF transcription factor 1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Fibrillar Center Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle	Nuclear Chromatin Nucleus
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding Protein Dimerization Activity C2H2 Zinc Finger Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Humoral Immune Response Multicellular Organism Development Spermatogenesis Aging Animal Organ Morphogenesis Lateral Ventricle Development Cerebral Cortex Development Adult Behavior Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Histone H3-K9 Methylation	Multicellular Organism Development Positive Regulation Of Transcription By RNA Polymerase II
Pathways		RUNX1 regulates transcription of genes involved in BCR signaling	Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases		Lymphoplasmacytic lymphoma
GWAS		Alzheimer's disease ( 30636644) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Coronary artery disease in type 1 diabetes ( 29695241) HIV-1 susceptibility ( 25786224) Intelligence ( 22449649) Major depressive disorder ( 27479909) Moderate to vigorous physical activity levels ( 29899525) Morning person ( 30696823) Obesity-related traits ( 22013104)	Adventurousness ( 30643258) Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Anorexia nervosa (excluding migration to or from binge-eating disorder or bulimia nervosa) ( 28630421) Birth weight ( 31043758 27680694) Blood pressure ( 21909110) Blood protein levels ( 29875488) Breast cancer ( 29059683 23535729 23535733) Carotid intima media thickness ( 26343869) Cognitive decline rate in late mild cognitive impairment ( 26252872) Creatine kinase levels ( 29403010) Diastolic blood pressure ( 28135244 27841878 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) General risk tolerance (MTAG) ( 30643258) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Hip circumference (psychosocial stress interaction) ( 25271088) Hypertension ( 21909115 30487518) Hypospadias ( 25108383) Inflammatory skin disease ( 25574825) Longevity (85 years and older) ( 24688116) Longevity (90 years and older) ( 24688116) Lymphocyte percentage of white cells ( 27863252) Male-pattern baldness ( 29146897 27182965 28196072) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte percentage of white cells ( 27863252) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pericardial adipose tissue adjusted for height and weight ( 27918534) Pericardial fat ( 27918534) Post bronchodilator FEV1 ( 26634245) Preterm birth (maternal effect) ( 28877031) Pulse pressure ( 30224653 28135244 27841878 28739976 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 26390057 28135244 27841878 21909115 28739976 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes (adjusted for BMI) ( 30297969)
Interacting Genes		16 interacting genes: CREBBP DAXX EBF1 EP300 ETS1 ID2 ID3 KPNA1 KPNA2 MAPK1 MYB RB1 RUNX1 TBP TLE4 UBE3A	8 interacting genes: ATPAF2 CREBBP ERO1A HOMEZ MTNR1B PAX5 ZNF423 ZNF521
Entrez ID		5079	1879
HPRD ID		01334	01256
Ensembl ID		ENSG00000196092	ENSG00000164330
Uniprot IDs		C0KTE5 C0KTF5 E7EQT0 E7ERK2 E7ERW5 E7ES87 Q02548	B4E2U8 Q9UH73
PDB IDs		1K78 1MDM	3LYR 3MQI
Enriched GO Terms of Interacting Partners?
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