KPNA1 and USP1

Number of citations of the paper that reports this interaction (PubMedID 21466675)
9

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		KPNA1	USP1
Description		karyopherin subunit alpha 1	ubiquitin specific peptidase 1
Image
GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Dendrite Host Cell Glutamatergic Synapse	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity Thiol-dependent Ubiquitinyl Hydrolase Activity
	Biological Process	Regulation Of DNA Recombination Apoptotic DNA Fragmentation NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Process Intracellular Transport Of Virus Postsynapse To Nucleus Signaling Pathway	Skeletal System Development Regulation Of DNA Repair Ubiquitin-dependent Protein Catabolic Process Response To UV Protein Deubiquitination Monoubiquitinated Protein Deubiquitination Interstrand Cross-link Repair DNA Damage Response, Detection Of DNA Damage
Pathways		ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Integration of provirus Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Vpr-mediated nuclear import of PICs Inhibition of nitric oxide production	Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Calcium levels ( 20705733) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Crohn's disease ( 26192919 28067908) Lipid traits ( 24386095) Metabolic syndrome ( 31589552) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels (CMS) ( 31636271) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		39 interacting genes: ANP32A ANP32B ARNT BCAR3 CDKN1B CLK4 CRADD CSE1L ELAVL1 EPAS1 FOSL1 GOPC GTF2IRD1 H2BC21 H3-4 HDAC6 HIF1A IL1RAP KPNB1 LEF1 LMO4 MDM2 NOSIP NUP54 NUP62 ORC4 PAX5 PKM RAG1 RANBP2 RUNX1T1 SENP2 SKP2 SRP19 STAT1 STAT3 TAF9 UBR5 USP1	12 interacting genes: DTX3 FANCD2 FANCI KLHDC2 KPNA1 PCNA PHF7 TRAF6 TRIM46 UBB UBC UBE2K
Entrez ID		3836	7398
HPRD ID		02819	04593
Ensembl ID		ENSG00000114030	ENSG00000162607
Uniprot IDs		B3KXZ2 P52294	O94782
PDB IDs		2JDQ 3TJ3 4B18	6DO5
Enriched GO Terms of Interacting Partners?
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