KPNA1 and CRADD

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		KPNA1	CRADD
Description		karyopherin subunit alpha 1	CASP2 and RIPK1 domain containing adaptor with death domain
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GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Dendrite Host Cell Glutamatergic Synapse	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Protease Binding Protein Binding Protein Binding, Bridging Death Domain Binding
	Biological Process	Regulation Of DNA Recombination Apoptotic DNA Fragmentation NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Process Intracellular Transport Of Virus Postsynapse To Nucleus Signaling Pathway	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway
Pathways		ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Integration of provirus Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Vpr-mediated nuclear import of PICs Inhibition of nitric oxide production	TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS		Calcium levels ( 20705733) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Alzheimer's disease (cognitive decline) ( 23535033) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 25282103 31562340 18391951 31217584) Hip circumference adjusted for BMI ( 25673412) Lung function (FVC) ( 30061609 30804560) Pulse pressure ( 27841878) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		39 interacting genes: ANP32A ANP32B ARNT BCAR3 CDKN1B CLK4 CRADD CSE1L ELAVL1 EPAS1 FOSL1 GOPC GTF2IRD1 H2BC21 H3-4 HDAC6 HIF1A IL1RAP KPNB1 LEF1 LMO4 MDM2 NOSIP NUP54 NUP62 ORC4 PAX5 PKM RAG1 RANBP2 RUNX1T1 SENP2 SKP2 SRP19 STAT1 STAT3 TAF9 UBR5 USP1	20 interacting genes: ACTN2 APP APPL2 BBS5 CASP2 CASP8 CCSER2 DCXR EEF1A1 ERG28 IL9R KCTD9 KPNA1 LRIF1 PIDD1 RIPK1 SLC35A3 TRIM54 VTN WIF1
Entrez ID		3836	8738
HPRD ID		02819	04584
Ensembl ID		ENSG00000114030	ENSG00000169372
Uniprot IDs		B3KXZ2 P52294	B4DJT6 F5H7C2 F8VV49 F8VVY5 P78560 Q53XL1 Q8IY43
PDB IDs		2JDQ 3TJ3 4B18	2O71 2OF5 3CRD
Enriched GO Terms of Interacting Partners?
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