MYO6 and GIPC1

Number of citations of the paper that reports this interaction (PubMedID 12857860)
89

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		MYO6	GIPC1
Description		myosin VI	GIPC PDZ domain containing family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Actin Filament Plasma Membrane Microvillus Clathrin-coated Pit Cell Cortex Actin Cytoskeleton Membrane Unconventional Myosin Complex RNA Polymerase II, Holoenzyme Endocytic Vesicle Filopodium Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Filamentous Actin Nuclear Membrane Vesicle Ruffle Membrane Cell Projection Apical Part Of Cell Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Cytosol Brush Border Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Endocytic Vesicle Cytoplasmic Vesicle Dendritic Spine Dendritic Shaft Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Microfilament Motor Activity Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Actin-dependent ATPase Activity ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity	Actin Binding Signaling Receptor Binding Protein Binding Myosin Binding PDZ Domain Binding Identical Protein Binding Cadherin Binding
	Biological Process	Intracellular Protein Transport Endocytosis Actin Filament Organization Sensory Perception Of Sound Actin Filament-based Movement Vesicle Transport Along Actin Filament DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Response To Drug Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Secretion	Protein Targeting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Positive Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Cellular Response To Interleukin-7 Regulation Of Synaptic Vesicle Exocytosis
Pathways		Gap junction degradation Trafficking of AMPA receptors
Drugs
Diseases		Deafness, autosomal dominant Deafness, autosomal recessive
GWAS		Prostate cancer ( 25217961) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Kidney stones ( 31729369)
Interacting Genes		19 interacting genes: ACTA1 APC CALCOCO2 CALM2 CDC42 CDH1 DAB1 DAB2 DLG1 GIPC1 LRCH3 OPTN PAK1 PAK3 RNF11 TOM1 TOM1L2 UBC WBP2	37 interacting genes: ACTN1 ADRB1 ARHGEF12 BRD4 CARD10 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KIF1B LHCGR LPAR1 LPAR2 LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SH3BP4 SLC2A1 TGFBR3 TPBG TYRP1 ZFPM1 ZNF408
Entrez ID		4646	10755
HPRD ID		02985	05462
Ensembl ID		ENSG00000196586	ENSG00000123159
Uniprot IDs		Q9UM54	A0A024R7I0 A0A024R7I1 A8K2I7 O14908
PDB IDs		2N0Z 2N10 2N11 2N12 2N13 6E5N 6J56
Enriched GO Terms of Interacting Partners?
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