MYO6 and LRCH3

Number of citations of the paper that reports this interaction (PubMedID 29467281)
4

Data Source:
BioGRID (two hybrid)

		MYO6	LRCH3
Description		myosin VI	leucine rich repeats and calponin homology domain containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Actin Filament Plasma Membrane Microvillus Clathrin-coated Pit Cell Cortex Actin Cytoskeleton Membrane Unconventional Myosin Complex RNA Polymerase II, Holoenzyme Endocytic Vesicle Filopodium Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Filamentous Actin Nuclear Membrane Vesicle Ruffle Membrane Cell Projection Apical Part Of Cell Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Microfilament Motor Activity Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Actin-dependent ATPase Activity ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity	Protein Binding
	Biological Process	Intracellular Protein Transport Endocytosis Actin Filament Organization Sensory Perception Of Sound Actin Filament-based Movement Vesicle Transport Along Actin Filament DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Response To Drug Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Secretion	Septin Cytoskeleton Organization
Pathways		Gap junction degradation Trafficking of AMPA receptors
Drugs
Diseases		Deafness, autosomal dominant Deafness, autosomal recessive
GWAS		Prostate cancer ( 25217961) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Airway responsiveness in chronic obstructive pulmonary disease ( 25514360)
Interacting Genes		19 interacting genes: ACTA1 APC CALCOCO2 CALM2 CDC42 CDH1 DAB1 DAB2 DLG1 GIPC1 LRCH3 OPTN PAK1 PAK3 RNF11 TOM1 TOM1L2 UBC WBP2	2 interacting genes: MYO6 YWHAG
Entrez ID		4646	84859
HPRD ID		02985	14308
Ensembl ID		ENSG00000196586	ENSG00000186001
Uniprot IDs		Q9UM54	B4DU23 Q96II8
PDB IDs		2N0Z 2N10 2N11 2N12 2N13 6E5N 6J56
Enriched GO Terms of Interacting Partners?
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