MYO6 and PAK3

Number of citations of the paper that reports this interaction (PubMedID 11517222)
11

Data Source:
HPRD (in vitro, in vivo)

		MYO6	PAK3
Description		myosin VI	p21 (RAC1) activated kinase 3
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GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Actin Filament Plasma Membrane Microvillus Clathrin-coated Pit Cell Cortex Actin Cytoskeleton Membrane Unconventional Myosin Complex RNA Polymerase II, Holoenzyme Endocytic Vesicle Filopodium Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Filamentous Actin Nuclear Membrane Vesicle Ruffle Membrane Cell Projection Apical Part Of Cell Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Endosome Cytosol Plasma Membrane Postsynaptic Density Glutamatergic Synapse
	Molecular Function	Microfilament Motor Activity Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Actin-dependent ATPase Activity ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Rho GTPase Binding SH3 Domain Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Endocytosis Actin Filament Organization Sensory Perception Of Sound Actin Filament-based Movement Vesicle Transport Along Actin Filament DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Response To Drug Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Secretion	MAPK Cascade Activation Of MAPK Activity Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Axonogenesis Positive Regulation Of Fibroblast Migration Dendrite Development Signal Transduction By Protein Phosphorylation Regulation Of Actin Filament Polymerization Stress-activated Protein Kinase Signaling Cascade T Cell Costimulation Activation Of Protein Kinase Activity Positive Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Regulation Of Axonogenesis Synapse Organization T Cell Receptor Signaling Pathway Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Organic Cyclic Compound Positive Regulation Of DNA Biosynthetic Process
Pathways		Gap junction degradation Trafficking of AMPA receptors	Generation of second messenger molecules CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling
Drugs
Diseases		Deafness, autosomal dominant Deafness, autosomal recessive	Non-syndromic X-linked mental retardation
GWAS		Prostate cancer ( 25217961) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		19 interacting genes: ACTA1 APC CALCOCO2 CALM2 CDC42 CDH1 DAB1 DAB2 DLG1 GIPC1 LRCH3 OPTN PAK1 PAK3 RNF11 TOM1 TOM1L2 UBC WBP2	12 interacting genes: ARHGEF6 ARHGEF7 CDC42 GIT1 GIT2 MYO6 NCK1 PXN RAC1 RAF1 SNCA SYN1
Entrez ID		4646	5063
HPRD ID		02985	02142
Ensembl ID		ENSG00000196586	ENSG00000077264
Uniprot IDs		Q9UM54	B2RCU6 O75914
PDB IDs		2N0Z 2N10 2N11 2N12 2N13 6E5N 6J56	6FD3
Enriched GO Terms of Interacting Partners?
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