MYH9 and MYOM1

Number of citations of the paper that reports this interaction (PubMedID 7588733)
10

Data Source:
HPRD (in vitro)

		MYH9	MYOM1
Description		myosin heavy chain 9	myomesin 1
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GO Annotations	Cellular Component	Stress Fiber Ruffle Immunological Synapse Uropod Cell Nucleus Cytoplasm Spindle Actomyosin Contractile Ring Cytosol Plasma Membrane Brush Border Adherens Junction Focal Adhesion COP9 Signalosome Actin Cytoskeleton Membrane Myosin II Complex Cell Leading Edge Neuromuscular Junction Cleavage Furrow Protein-containing Complex Actomyosin Extracellular Exosome Myosin II Filament	Striated Muscle Myosin Thick Filament Striated Muscle Thin Filament Sarcomere Z Disc M Band
	Molecular Function	Microfilament Motor Activity RNA Binding Motor Activity Actin Binding Integrin Binding Protein Binding Calmodulin Binding ATP Binding ATPase Activity Protein Domain Specific Binding Actin-dependent ATPase Activity Protein Homodimerization Activity Protein Membrane Anchor ADP Binding Cadherin Binding Actin Filament Binding	Protein Binding Structural Constituent Of Muscle Kinase Binding Identical Protein Binding Protein Homodimerization Activity Actin Filament Binding Muscle Alpha-actinin Binding
	Biological Process	Meiotic Spindle Organization Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Plasma Membrane Repair Membrane Protein Ectodomain Proteolysis Phagocytosis, Engulfment Integrin-mediated Signaling Pathway Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Lysosome Localization Cytokinetic Process Uropod Organization Blood Vessel Endothelial Cell Migration Regulated Exocytosis Leukocyte Migration Establishment Of Meiotic Spindle Localization Platelet Aggregation Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Regulation Of Plasma Membrane Repair	Extraocular Skeletal Muscle Development Muscle Contraction Striated Muscle Contraction Actin Filament Organization Positive Regulation Of Gene Expression Protein Kinase A Signaling Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Sarcomere Organization Cardiac Muscle Fiber Development Positive Regulation Of Protein Secretion Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Striated Muscle Myosin Thick Filament Assembly
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs CD163 mediating an anti-inflammatory response FCGR3A-mediated phagocytosis
Drugs
Diseases		Macrothrombocytopenia; May-Hegglin anomaly; Sebastian syndrome; Fechtner syndrome; Epstein syndrome Deafness, autosomal dominant MYH9-related kidney diseases, including: Epstein syndrome; Fechtner syndrome
GWAS		Diabetic kidney disease ( 26305897) End-stage renal disease (non-diabetic) ( 20532800) Glomerulosclerosis ( 20668430) Heel bone mineral density ( 30598549) Hip circumference ( 30108283) Language performance in older adults (adjusted for episodic memory) ( 28577822) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Optic nerve measurement (rim area) ( 20395239)	Brain volume in infants (white matter) ( 28763065) Night sleep phenotypes ( 27126917) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)
Interacting Genes		24 interacting genes: ASCC2 CASP4 CBL CD163 CSNK2A1 CXCR4 GRB2 GRIN1 MEN1 MTDH MYBPC3 MYH10 MYL9 MYOM1 MYOM2 OVGP1 PPP2CA PTPN6 RAC1 S100A4 TTN TUFM UBE2I YWHAZ	3 interacting genes: CLK1 MYH9 TTN
Entrez ID		4627	8736
HPRD ID		01177	04618
Ensembl ID		ENSG00000100345	ENSG00000101605
Uniprot IDs		A0A024R1N1 P35579	P52179
PDB IDs		2LNK 3ZWH 4CFQ 4CFR 4ETO	2R15 2Y23 2Y25 3RBS 5FM4 5FM5 5FM8
Enriched GO Terms of Interacting Partners?
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