MYH9 and MYOM2

Number of citations of the paper that reports this interaction (PubMedID 9529381)
23

Data Source:
HPRD (in vitro)

		MYH9	MYOM2
Description		myosin heavy chain 9	myomesin 2
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Ruffle Immunological Synapse Uropod Cell Nucleus Cytoplasm Spindle Actomyosin Contractile Ring Cytosol Plasma Membrane Brush Border Adherens Junction Focal Adhesion COP9 Signalosome Actin Cytoskeleton Membrane Myosin II Complex Cell Leading Edge Neuromuscular Junction Cleavage Furrow Protein-containing Complex Actomyosin Extracellular Exosome Myosin II Filament	Mitochondrion Striated Muscle Thin Filament Sarcomere Z Disc M Band Myosin Filament
	Molecular Function	Microfilament Motor Activity RNA Binding Motor Activity Actin Binding Integrin Binding Protein Binding Calmodulin Binding ATP Binding ATPase Activity Protein Domain Specific Binding Actin-dependent ATPase Activity Protein Homodimerization Activity Protein Membrane Anchor ADP Binding Cadherin Binding Actin Filament Binding	Protein Binding Structural Constituent Of Muscle Kinase Binding Actin Filament Binding Muscle Alpha-actinin Binding
	Biological Process	Meiotic Spindle Organization Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Plasma Membrane Repair Membrane Protein Ectodomain Proteolysis Phagocytosis, Engulfment Integrin-mediated Signaling Pathway Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Lysosome Localization Cytokinetic Process Uropod Organization Blood Vessel Endothelial Cell Migration Regulated Exocytosis Leukocyte Migration Establishment Of Meiotic Spindle Localization Platelet Aggregation Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Regulation Of Plasma Membrane Repair	Extraocular Skeletal Muscle Development Muscle Contraction Striated Muscle Contraction Actin Filament Organization Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Sarcomere Organization Cardiac Muscle Fiber Development Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Striated Muscle Myosin Thick Filament Assembly
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs CD163 mediating an anti-inflammatory response FCGR3A-mediated phagocytosis
Drugs
Diseases		Macrothrombocytopenia; May-Hegglin anomaly; Sebastian syndrome; Fechtner syndrome; Epstein syndrome Deafness, autosomal dominant MYH9-related kidney diseases, including: Epstein syndrome; Fechtner syndrome
GWAS		Diabetic kidney disease ( 26305897) End-stage renal disease (non-diabetic) ( 20532800) Glomerulosclerosis ( 20668430) Heel bone mineral density ( 30598549) Hip circumference ( 30108283) Language performance in older adults (adjusted for episodic memory) ( 28577822) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Optic nerve measurement (rim area) ( 20395239)	Ankylosing spondylitis ( 30946743) Diisocyanate-induced asthma ( 25918132) Heschl's gyrus morphology ( 25130324) Metabolite levels ( 23823483) Toenail selenium levels ( 25343990)
Interacting Genes		24 interacting genes: ASCC2 CASP4 CBL CD163 CSNK2A1 CXCR4 GRB2 GRIN1 MEN1 MTDH MYBPC3 MYH10 MYL9 MYOM1 MYOM2 OVGP1 PPP2CA PTPN6 RAC1 S100A4 TTN TUFM UBE2I YWHAZ	4 interacting genes: CKM HSPB2 MYH9 TTN
Entrez ID		4627	9172
HPRD ID		01177	04619
Ensembl ID		ENSG00000100345	ENSG00000036448
Uniprot IDs		A0A024R1N1 P35579	P54296
PDB IDs		2LNK 3ZWH 4CFQ 4CFR 4ETO
Enriched GO Terms of Interacting Partners?
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