MYH9 and MYH10

Number of citations of the paper that reports this interaction (PubMedID 26496610)
285

Data Source:
BioGRID (affinity chromatography technology, biochemical)
HPRD (two hybrid, in vivo)

		MYH9	MYH10
Description		myosin heavy chain 9	myosin heavy chain 10
Image
GO Annotations	Cellular Component	Stress Fiber Ruffle Immunological Synapse Uropod Cell Nucleus Cytoplasm Spindle Actomyosin Contractile Ring Cytosol Plasma Membrane Brush Border Adherens Junction Focal Adhesion COP9 Signalosome Actin Cytoskeleton Membrane Myosin II Complex Cell Leading Edge Neuromuscular Junction Cleavage Furrow Protein-containing Complex Actomyosin Extracellular Exosome Myosin II Filament	Stress Fiber Nucleus Cytoplasm Spindle Cytosol Polysome Brush Border Cell Cortex Myosin Complex Myosin II Complex Lamellipodium Growth Cone Midbody Neuromuscular Junction Cleavage Furrow Actomyosin Neuronal Cell Body Dendritic Spine Extracellular Exosome Myosin II Filament Glutamatergic Synapse
	Molecular Function	Microfilament Motor Activity RNA Binding Motor Activity Actin Binding Integrin Binding Protein Binding Calmodulin Binding ATP Binding ATPase Activity Protein Domain Specific Binding Actin-dependent ATPase Activity Protein Homodimerization Activity Protein Membrane Anchor ADP Binding Cadherin Binding Actin Filament Binding	Microfilament Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ATPase Activity Actin-dependent ATPase Activity RNA Stem-loop Binding ADP Binding MRNA 5'-UTR Binding Actin Filament Binding
	Biological Process	Meiotic Spindle Organization Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Plasma Membrane Repair Membrane Protein Ectodomain Proteolysis Phagocytosis, Engulfment Integrin-mediated Signaling Pathway Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Lysosome Localization Cytokinetic Process Uropod Organization Blood Vessel Endothelial Cell Migration Regulated Exocytosis Leukocyte Migration Establishment Of Meiotic Spindle Localization Platelet Aggregation Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Regulation Of Plasma Membrane Repair	Mitotic Cytokinesis In Utero Embryonic Development Neuron Migration Plasma Membrane Repair Cardiac Septum Development Exocytosis Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Cell Adhesion Axon Guidance Adult Heart Development Cell Proliferation Regulation Of Cell Shape Fourth Ventricle Development Lateral Ventricle Development Third Ventricle Development Cerebellar Purkinje Cell Layer Development Actin Filament-based Movement Actomyosin Structure Organization Aorta Development Positive Regulation Of Protein Secretion Neuromuscular Process Controlling Balance Cardiac Myofibril Assembly Ventricular Cardiac Muscle Cell Development Retina Development In Camera-type Eye Coronary Vasculature Development Modification Of Postsynaptic Actin Cytoskeleton Postsynaptic Actin Cytoskeleton Organization
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs CD163 mediating an anti-inflammatory response FCGR3A-mediated phagocytosis	EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs
Diseases		Macrothrombocytopenia; May-Hegglin anomaly; Sebastian syndrome; Fechtner syndrome; Epstein syndrome Deafness, autosomal dominant MYH9-related kidney diseases, including: Epstein syndrome; Fechtner syndrome
GWAS		Diabetic kidney disease ( 26305897) End-stage renal disease (non-diabetic) ( 20532800) Glomerulosclerosis ( 20668430) Heel bone mineral density ( 30598549) Hip circumference ( 30108283) Language performance in older adults (adjusted for episodic memory) ( 28577822) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Optic nerve measurement (rim area) ( 20395239)	Type 2 diabetes ( 30130595)
Interacting Genes		24 interacting genes: ASCC2 CASP4 CBL CD163 CSNK2A1 CXCR4 GRB2 GRIN1 MEN1 MTDH MYBPC3 MYH10 MYL9 MYOM1 MYOM2 OVGP1 PPP2CA PTPN6 RAC1 S100A4 TTN TUFM UBE2I YWHAZ	10 interacting genes: APC BCAP31 ECPAS MYH9 PBX1 PTEN S100A4 YWHAE YWHAG ZNF512B
Entrez ID		4627	4628
HPRD ID		01177	01178
Ensembl ID		ENSG00000100345	ENSG00000133026
Uniprot IDs		A0A024R1N1 P35579	G1UI33 P35580
PDB IDs		2LNK 3ZWH 4CFQ 4CFR 4ETO	4PD3
Enriched GO Terms of Interacting Partners?
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