MTHFR and DDX21

		MTHFR	DDX21
Description		methylenetetrahydrofolate reductase	DExD-box helicase 21
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GO Annotations	Cellular Component	Cytosol Synapse	Nucleoplasm Nucleolus Mitochondrion Cytosol Membrane
	Molecular Function	Methylenetetrahydrofolate Reductase (NAD(P)H) Activity Protein-containing Complex Binding Flavin Adenine Dinucleotide Binding NADP Binding FAD Binding Modified Amino Acid Binding	RNA Binding RNA Helicase Activity Double-stranded RNA Binding Protein Binding ATP Binding RRNA Binding SnoRNA Binding MiRNA Binding Identical Protein Binding 7SK SnRNA Binding
	Biological Process	Response To Hypoxia Neural Tube Closure Methionine Metabolic Process One-carbon Metabolic Process Methionine Biosynthetic Process Regulation Of Histone Methylation Response To Vitamin B2 Tetrahydrofolate Interconversion Response To Amino Acid S-adenosylmethionine Metabolic Process Folic Acid Metabolic Process Homocysteine Metabolic Process Response To Folic Acid Oxidation-reduction Process Response To Interleukin-1 Heterochromatin Maintenance	Osteoblast Differentiation Positive Regulation Of Myeloid Dendritic Cell Cytokine Production RRNA Processing Transcription By RNA Polymerase II Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Gene Expression, Epigenetic Defense Response To Virus
Pathways		Metabolism of folate and pterines	B-WICH complex positively regulates rRNA expression Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Cyanocobalamin Tetrahydrofolic acid
Diseases		Spina bifida Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Homocystinuria
GWAS		Atrial fibrillation ( 19597492) Blood pressure ( 21909110) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878 28739976 27618452 29615537) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Folate pathway vitamin levels ( 19744961) High altitude adaptation ( 28373541) Homocysteine levels ( 23824729 20031578 23696881) Hypertension ( 31879980) Mean arterial pressure ( 27618448) Medication use (calcium channel blockers) ( 31015401) Midregional pro atrial natriuretic peptide levels ( 29237677) Moyamoya disease ( 29273593) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Plasma homocysteine levels ( 30339177) Pulse pressure ( 27841878) Red blood cell folate levels ( 30339177) Serum folate levels ( 30339177 29953918) Systolic blood pressure ( 19430483 27841878 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)	Depression (quantitative trait) ( 20800221)
Interacting Genes		2 interacting genes: DDX21 LSM8	18 interacting genes: ADAMTS14 CALM1 CSNK2A1 ERG H2AX IL7R JUN KPNA3 MTHFR PIAS1 PNMA2 SGPL1 SRPK2 SUMO2 TERF1 TERF2 TET1 UBE2I
Entrez ID		4524	9188
HPRD ID		06158	05895
Ensembl ID		ENSG00000177000	ENSG00000165732
Uniprot IDs		P42898 Q59GJ6 Q5SNW7 Q8IU67	Q9NR30
PDB IDs		6FCX	2M3D
Enriched GO Terms of Interacting Partners?
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