DDX21 and ADAMTS14

		DDX21	ADAMTS14
Description		DExD-box helicase 21	ADAM metallopeptidase with thrombospondin type 1 motif 14
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Mitochondrion Cytosol Membrane	Extracellular Region
	Molecular Function	RNA Binding RNA Helicase Activity Double-stranded RNA Binding Protein Binding ATP Binding RRNA Binding SnoRNA Binding MiRNA Binding Identical Protein Binding 7SK SnRNA Binding	Metalloendopeptidase Activity Metal Ion Binding
	Biological Process	Osteoblast Differentiation Positive Regulation Of Myeloid Dendritic Cell Cytokine Production RRNA Processing Transcription By RNA Polymerase II Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Gene Expression, Epigenetic Defense Response To Virus	Proteolysis Collagen Fibril Organization Collagen Catabolic Process
Pathways		B-WICH complex positively regulates rRNA expression Major pathway of rRNA processing in the nucleolus and cytosol	Collagen biosynthesis and modifying enzymes Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Depression (quantitative trait) ( 20800221)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Heel bone mineral density ( 30598549) Moderate-to-late spontaneous preterm birth ( 31194736) Optic disc size ( 31809533) Sleep duration ( 23728906) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Suicide behavior ( 26079190)
Interacting Genes		18 interacting genes: ADAMTS14 CALM1 CSNK2A1 ERG H2AX IL7R JUN KPNA3 MTHFR PIAS1 PNMA2 SGPL1 SRPK2 SUMO2 TERF1 TERF2 TET1 UBE2I	1 interacting genes: DDX21
Entrez ID		9188	140766
HPRD ID		05895	06329
Ensembl ID		ENSG00000165732	ENSG00000138316
Uniprot IDs		Q9NR30	Q8WXS8
PDB IDs		2M3D
Enriched GO Terms of Interacting Partners?
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