MTHFR

Description		methylenetetrahydrofolate reductase
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GO Annotations	Cellular Component	Cytosol Synapse
	Molecular Function	Methylenetetrahydrofolate Reductase (NAD(P)H) Activity Protein-containing Complex Binding Flavin Adenine Dinucleotide Binding NADP Binding FAD Binding Modified Amino Acid Binding
	Biological Process	Response To Hypoxia Neural Tube Closure Methionine Metabolic Process One-carbon Metabolic Process Methionine Biosynthetic Process Regulation Of Histone Methylation Response To Vitamin B2 Tetrahydrofolate Interconversion Response To Amino Acid S-adenosylmethionine Metabolic Process Folic Acid Metabolic Process Homocysteine Metabolic Process Response To Folic Acid Oxidation-reduction Process Response To Interleukin-1 Heterochromatin Maintenance
Pathways		Metabolism of folate and pterines
Drugs		Cyanocobalamin Tetrahydrofolic acid
Diseases		Spina bifida Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Homocystinuria
GWAS		Atrial fibrillation ( 19597492) Blood pressure ( 21909110) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878 28739976 27618452 29615537) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Folate pathway vitamin levels ( 19744961) High altitude adaptation ( 28373541) Homocysteine levels ( 23824729 20031578 23696881) Hypertension ( 31879980) Mean arterial pressure ( 27618448) Medication use (calcium channel blockers) ( 31015401) Midregional pro atrial natriuretic peptide levels ( 29237677) Moyamoya disease ( 29273593) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Plasma homocysteine levels ( 30339177) Pulse pressure ( 27841878) Red blood cell folate levels ( 30339177) Serum folate levels ( 30339177 29953918) Systolic blood pressure ( 19430483 27841878 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)
Interacting Genes		2 interacting genes: DDX21 LSM8
Entrez ID		4524
HPRD ID		06158
Ensembl ID		ENSG00000177000
Uniprot IDs		P42898 Q59GJ6 Q5SNW7 Q8IU67
PDB IDs		6FCX
Enriched GO Terms of Interacting Partners?
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