MT2A and RCHY1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MT2A	RCHY1
Description		metallothionein 2A	ring finger and CHY zinc finger domain containing 1
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GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Drug Binding Zinc Ion Binding Metal Ion Binding	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity
	Biological Process	Cellular Copper Ion Homeostasis Cellular Zinc Ion Homeostasis Response To Metal Ion Detoxification Of Copper Ion Cellular Response To Drug Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Interferon-gamma-mediated Signaling Pathway Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Error-free Translesion Synthesis
Pathways		Metallothioneins bind metals Metallothioneins bind metals Interferon gamma signaling	Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Zinc
Diseases
GWAS			Metabolite levels ( 23823483) Response to tocilizumab in rheumatoid arthritis ( 22491018)
Interacting Genes		20 interacting genes: ADAMTS4 ARF6 ASS1 BARD1 DHODH ECT2 EOLA1 HMGB1 JMJD1C LAMTOR5 MCPH1 PAXIP1 PRKD1 RCHY1 RIN3 SHBG SPINK7 STOM TNS2 USP25	69 interacting genes: ADAMTSL4 AIG1 ANGPTL8 AOX1 AR ARF4 ATN1 BIRC3 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CYBA DAPK1 DCUN1D5 F7 FADS6 GFI1B GORAB HOXA2 HOXB1 HOXB5 HOXC4 HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MDM2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NLA PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPLP1 RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 WDR74 ZNF160
Entrez ID		4502	25898
HPRD ID		08863	07607
Ensembl ID		ENSG00000125148	ENSG00000163743
Uniprot IDs		P02795	Q96PM5
PDB IDs		1MHU 2MHU	2JRJ 2K2C 2K2D
Enriched GO Terms of Interacting Partners?
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