RCHY1 and WDR74

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		RCHY1	WDR74
Description		ring finger and CHY zinc finger domain containing 1	WD repeat domain 74
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Intracellular Membrane-bounded Organelle	Nuclear Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Preribosome, Large Subunit Precursor
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Error-free Translesion Synthesis	Blastocyst Formation RRNA Processing RNA Metabolic Process Ribosomal Large Subunit Biogenesis
Pathways		Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Response to tocilizumab in rheumatoid arthritis ( 22491018)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		69 interacting genes: ADAMTSL4 AIG1 ANGPTL8 AOX1 AR ARF4 ATN1 BIRC3 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CYBA DAPK1 DCUN1D5 F7 FADS6 GFI1B GORAB HOXA2 HOXB1 HOXB5 HOXC4 HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MDM2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NLA PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPLP1 RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 WDR74 ZNF160	4 interacting genes: NUDT3 RCHY1 RGS2 YIF1A
Entrez ID		25898	54663
HPRD ID		07607	08548
Ensembl ID		ENSG00000163743	ENSG00000133316
Uniprot IDs		Q96PM5	Q6RFH5
PDB IDs		2JRJ 2K2C 2K2D
Enriched GO Terms of Interacting Partners?
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