ATXN3 and CAPN1

Number of citations of the paper that reports this interaction (PubMedID 28334907)
6

Data Source:
BioGRID (unspecified method)

		ATXN3	CAPN1
Description		ataxin 3	calpain 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrial Matrix Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Nuclear Matrix Mitochondrial Membrane Nuclear Inclusion Body Synapse	Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Regulatory Region DNA Binding Histone Deacetylase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Ubiquitin Protein Ligase Binding Thiol-dependent Ubiquitinyl Hydrolase Activity ATPase Binding Lys63-specific Deubiquitinase Activity Lys48-specific Deubiquitinase Activity	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Chemical Synaptic Transmission Nervous System Development Regulation Of Cell-substrate Adhesion Protein Deubiquitination Actin Cytoskeleton Organization Cellular Response To Heat Monoubiquitinated Protein Deubiquitination Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Protein K63-linked Deubiquitination Histone H3 Deacetylation Protein K48-linked Deubiquitination Cellular Response To Misfolded Protein Positive Regulation Of ERAD Pathway Protein Localization To Cytosolic Proteasome Complex Involved In ERAD Pathway	Proteolysis Positive Regulation Of Cell Proliferation Regulation Of Macroautophagy Extracellular Matrix Disassembly Receptor Catabolic Process Neutrophil Degranulation Regulation Of Catalytic Activity Mammary Gland Involution Cornification Self Proteolysis Regulation Of NMDA Receptor Activity
Pathways		Josephin domain DUBs FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			N-[N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-Butyl]-Guanidine CBZ-LEU-LEU-TYR-CH2F (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Amyotrophic lateral sclerosis ( 29566793) Coronary artery calcification ( 23870195) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Height ( 18391950 18391951) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Orofacial clefts ( 22419666)	Urate levels ( 31578528)
Interacting Genes		50 interacting genes: ANXA7 APP ARHGAP19 ARHGDIA ASIC1 C16orf70 CAPN1 CAPN2 CASP1 CDKN1A CHEK1 CSNK2B DNM2 EWSR1 GSK3B HDAC6 KAT2B MAP3K1 MKNK1 NCOR1 NEDD8 PICK1 PJA1 PRKN PSMD7 RAD23A RAD23B RFFL RPS6KA1 SMURF1 SQSTM1 STUB1 SUMO1 TEX11 TK1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TUBA1A TUBB UBB UBC UBE2L3 UBE2S UBE4B UBQLN1 USP21 VCP	54 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 ELOB F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM
Entrez ID		4287	823
HPRD ID		06131	00253
Ensembl ID		ENSG00000066427	ENSG00000014216
Uniprot IDs		A0A0A0MS38 C9JQV6 P54252	B2RDI5 B4DWH5 P07384
PDB IDs		1YZB 2AGA 2DOS 2JRI 2KLZ 4WTH 4YS9	1ZCM 2ARY
Enriched GO Terms of Interacting Partners?
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