ATXN3 and ASIC1

Number of citations of the paper that reports this interaction (PubMedID 15952105)
2

Data Source:
BioGRID (two hybrid)

		ATXN3	ASIC1
Description		ataxin 3	acid sensing ion channel subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrial Matrix Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Nuclear Matrix Mitochondrial Membrane Nuclear Inclusion Body Synapse	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Synapse
	Molecular Function	RNA Polymerase II Regulatory Region DNA Binding Histone Deacetylase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Ubiquitin Protein Ligase Binding Thiol-dependent Ubiquitinyl Hydrolase Activity ATPase Binding Lys63-specific Deubiquitinase Activity Lys48-specific Deubiquitinase Activity	Protein Binding Ligand-gated Sodium Channel Activity Ion Gated Channel Activity Acid-sensing Ion Channel Activity
	Biological Process	Microtubule Cytoskeleton Organization Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Chemical Synaptic Transmission Nervous System Development Regulation Of Cell-substrate Adhesion Protein Deubiquitination Actin Cytoskeleton Organization Cellular Response To Heat Monoubiquitinated Protein Deubiquitination Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Protein K63-linked Deubiquitination Histone H3 Deacetylation Protein K48-linked Deubiquitination Cellular Response To Misfolded Protein Positive Regulation Of ERAD Pathway Protein Localization To Cytosolic Proteasome Complex Involved In ERAD Pathway	Behavioral Fear Response Response To Amphetamine Sodium Ion Transport Signal Transduction Memory Associative Learning Response To PH Response To Acidic PH Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Neurotransmitter Secretion Sensory Perception Of Sour Taste Protein Homotrimerization Calcium Ion Transmembrane Transport Cellular Response To PH
Pathways		Josephin domain DUBs FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Stimuli-sensing channels
Drugs			Diclofenac Amiloride
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Amyotrophic lateral sclerosis ( 29566793) Coronary artery calcification ( 23870195) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Height ( 18391950 18391951) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Orofacial clefts ( 22419666)
Interacting Genes		50 interacting genes: ANXA7 APP ARHGAP19 ARHGDIA ASIC1 C16orf70 CAPN1 CAPN2 CASP1 CDKN1A CHEK1 CSNK2B DNM2 EWSR1 GSK3B HDAC6 KAT2B MAP3K1 MKNK1 NCOR1 NEDD8 PICK1 PJA1 PRKN PSMD7 RAD23A RAD23B RFFL RPS6KA1 SMURF1 SQSTM1 STUB1 SUMO1 TEX11 TK1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TUBA1A TUBB UBB UBC UBE2L3 UBE2S UBE4B UBQLN1 USP21 VCP	5 interacting genes: ASIC2 ATXN3 PICK1 PRKACA STOM
Entrez ID		4287	41
HPRD ID		06131	04182
Ensembl ID		ENSG00000066427	ENSG00000110881
Uniprot IDs		A0A0A0MS38 C9JQV6 P54252	A8K1U5 P78348
PDB IDs		1YZB 2AGA 2DOS 2JRI 2KLZ 4WTH 4YS9
Enriched GO Terms of Interacting Partners?
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