CAPN1 and NFE2L1

Number of citations of the paper that reports this interaction (PubMedID 12358155)
5

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CAPN1	NFE2L1
Description		calpain 1	nuclear factor, erythroid 2 like 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane Protein-containing Complex
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Coregulator Activity Protein Binding Cholesterol Binding Protein Domain Specific Binding Protein-containing Complex Binding Promoter-specific Chromatin Binding
	Biological Process	Proteolysis Positive Regulation Of Cell Proliferation Regulation Of Macroautophagy Extracellular Matrix Disassembly Receptor Catabolic Process Neutrophil Degranulation Regulation Of Catalytic Activity Mammary Gland Involution Cornification Self Proteolysis Regulation Of NMDA Receptor Activity	Protein Polyubiquitination Fructose 6-phosphate Metabolic Process Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Glutathione Metabolic Process Heme Biosynthetic Process Inflammatory Response Regulation Of Mitotic Nuclear Division Cholesterol Metabolic Process Anatomical Structure Morphogenesis Regulation Of Glucose Metabolic Process Regulation Of Fatty Acid Metabolic Process Cellular Homeostasis Spinal Cord Motor Neuron Differentiation Glial Cell Fate Commitment Erythrocyte Differentiation Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Cholesterol Homeostasis Cysteine Transport Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Glucose 6-phosphate Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Cold Cellular Response To Copper Ion Cellular Response To Cholesterol Regulation Of Nucleus Organization Regulation Of Response To Endoplasmic Reticulum Stress
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		N-[N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-Butyl]-Guanidine CBZ-LEU-LEU-TYR-CH2F (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE	Lauryl Dimethylamine-N-Oxide
Diseases
GWAS		Urate levels ( 31578528)	Generalized epilepsy ( 22949513) Heel bone mineral density ( 30598549)
Interacting Genes		54 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 ELOB F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM	15 interacting genes: ATF4 BACH2 CAPN1 CD6 CREBZF GSK3B HCFC1 JUN JUNB JUND MAFF MAFG MAFK NFE2L3 PARVA
Entrez ID		823	4779
HPRD ID		00253	01223
Ensembl ID		ENSG00000014216	ENSG00000082641
Uniprot IDs		B2RDI5 B4DWH5 P07384	J9JIE5 Q14494 Q8NF22
PDB IDs		1ZCM 2ARY
Enriched GO Terms of Interacting Partners?
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