CAPN1 and CAST

Number of citations of the paper that reports this interaction (PubMedID 26496610)
285

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology)
HPRD (in vitro)

		CAPN1	CAST
Description		calpain 1	calpastatin
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen	Cytoplasm Endoplasmic Reticulum Cytosol Membrane
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	RNA Binding Endopeptidase Inhibitor Activity Protein Binding Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Cadherin Binding
	Biological Process	Proteolysis Positive Regulation Of Cell Proliferation Regulation Of Macroautophagy Extracellular Matrix Disassembly Receptor Catabolic Process Neutrophil Degranulation Regulation Of Catalytic Activity Mammary Gland Involution Cornification Self Proteolysis Regulation Of NMDA Receptor Activity	Inhibition Of Cysteine-type Endopeptidase Activity Presynaptic Active Zone Organization Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		N-[N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-Butyl]-Guanidine CBZ-LEU-LEU-TYR-CH2F (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE	Calcium Artenimol
Diseases
GWAS		Urate levels ( 31578528)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alcohol dependence ( 19581569) Blood protein levels ( 28240269) Body mass index ( 26426971) Medication use (agents acting on the renin-angiotensin system) ( 31015401)
Interacting Genes		54 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 ELOB F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM	10 interacting genes: CAPN1 CAPNS1 CASP1 CASP3 CASP7 HTRA1 PPFIA1 PPFIA2 PPFIA3 PPFIA4
Entrez ID		823	831
HPRD ID		00253	00233
Ensembl ID		ENSG00000014216	ENSG00000153113
Uniprot IDs		B2RDI5 B4DWH5 P07384	B7Z6N0 E9PCH5 E9PDE4 P20810 Q59HE3 Q86YM9
PDB IDs		1ZCM 2ARY
Enriched GO Terms of Interacting Partners?
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