MEFV and GABARAPL1

Number of citations of the paper that reports this interaction (PubMedID 26347139)
65

Data Source:
BioGRID (pull down)

		MEFV	GABARAPL1
Description		MEFV innate immuity regulator, pyrin	GABA type A receptor associated protein like 1
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GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Microtubule Microtubule Associated Complex Lamellipodium Cytoplasmic Vesicle	Autophagosome Membrane Intracellular Mitochondrion Autophagosome Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule Cytoplasmic Vesicle Membrane Dendrite Membrane Dendrite Cytoplasm Cell Body
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Identical Protein Binding	Protein Binding Microtubule Binding Tat Protein Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding
	Biological Process	Inflammatory Response Positive Regulation Of Autophagy Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Response To Interferon-gamma Negative Regulation Of Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity	Autophagosome Assembly Autophagy Of Mitochondrion Cellular Response To Nitrogen Starvation Macroautophagy Autophagosome Maturation
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection	Macroautophagy
Drugs
Diseases		Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
GWAS		Ankylosing spondylitis ( 30946743)
Interacting Genes		12 interacting genes: COG5 GABARAP GABARAPL1 GABARAPL2 LGALS3 LGALS8 MAP1LC3A MAP1LC3C PSTPIP1 PYCARD SIVA1 ULK1	47 interacting genes: AHNAK2 AMBRA1 ANK2 ATG13 ATG4A ATG4D CALCOCO2 CUL3 DVL2 FUNDC1 KBTBD7 KRTAP10-3 KRTAP10-7 KRTAP10-9 KXD1 MAPK15 MEFV NEDD4 OPRK1 OPTN RABGAP1 RABGAP1L RB1CC1 RETREG3 SCYL3 SNCA SQSTM1 SRPK1 SRPK2 TAX1BP1 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B TNIP1 TRIM21 ULK1 VDR WDFY3
Entrez ID		4210	23710
HPRD ID		02012	07601
Ensembl ID		ENSG00000103313	ENSG00000139112
Uniprot IDs		D2DTW2 O15553	A0A024RAP5 Q9H0R8
PDB IDs		2MPC 2WL1 4CG4	2L8J 2R2Q 5DPT 5LXH 5LXI 6HOI 6HOL
Enriched GO Terms of Interacting Partners?
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