MEFV and SIVA1

Number of citations of the paper that reports this interaction (PubMedID 18330885)
9

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		MEFV	SIVA1
Description		MEFV innate immuity regulator, pyrin	SIVA1 apoptosis inducing factor
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Microtubule Microtubule Associated Complex Lamellipodium Cytoplasmic Vesicle	Nucleoplasm Cytoplasm
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Identical Protein Binding	Virus Receptor Activity Tumor Necrosis Factor Receptor Binding CD27 Receptor Binding Protein Binding Metal Ion Binding
	Biological Process	Inflammatory Response Positive Regulation Of Autophagy Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Response To Interferon-gamma Negative Regulation Of Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity	Viral Entry Into Host Cell Extrinsic Apoptotic Signaling Pathway
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs			Zinc
Diseases		Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
GWAS		Ankylosing spondylitis ( 30946743)	Endometrial cancer ( 27135401) Endometrial endometrioid carcinoma ( 27135401)
Interacting Genes		12 interacting genes: COG5 GABARAP GABARAPL1 GABARAPL2 LGALS3 LGALS8 MAP1LC3A MAP1LC3C PSTPIP1 PYCARD SIVA1 ULK1	20 interacting genes: ABL2 APP BAG5 BCL2L1 BEX3 CD27 CD4 CDKN2A MEFV NEDD4 NEDD4L PCNA POLR2M PXMP2 RAD18 RHOU SSBP3 TCAP TNFRSF4 UBE2D1
Entrez ID		4210	10572
HPRD ID		02012	16124
Ensembl ID		ENSG00000103313	ENSG00000184990
Uniprot IDs		D2DTW2 O15553	O15304
PDB IDs		2MPC 2WL1 4CG4
Enriched GO Terms of Interacting Partners?
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