MEFV and COG5

Number of citations of the paper that reports this interaction (PubMedID 10782044)
1

Data Source:
HPRD (two hybrid)

		MEFV	COG5
Description		MEFV innate immuity regulator, pyrin	component of oligomeric golgi complex 5
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Microtubule Microtubule Associated Complex Lamellipodium Cytoplasmic Vesicle	Golgi Membrane Nucleoplasm Golgi Apparatus Cytosol Membrane Golgi Transport Complex Trans-Golgi Network Membrane
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Identical Protein Binding	Molecular_function Protein Binding
	Biological Process	Inflammatory Response Positive Regulation Of Autophagy Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Response To Interferon-gamma Negative Regulation Of Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity	ER To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Protein Transport Inter-Golgi Cisterna Vesicle-mediated Transport
Pathways		The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection	COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases		Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
GWAS		Ankylosing spondylitis ( 30946743)	Atrial fibrillation ( 29892015) LDL cholesterol ( 30275531) Macular thickness ( 30535121) Medication use (beta blocking agents) ( 31015401) Metabolite levels ( 23823483) Osteoarthritis ( 20112360) Pulse pressure ( 30224653 30578418) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		12 interacting genes: COG5 GABARAP GABARAPL1 GABARAPL2 LGALS3 LGALS8 MAP1LC3A MAP1LC3C PSTPIP1 PYCARD SIVA1 ULK1	5 interacting genes: APC COG4 COG7 MEFV RAC1
Entrez ID		4210	10466
HPRD ID		02012	08436
Ensembl ID		ENSG00000103313	ENSG00000164597
Uniprot IDs		D2DTW2 O15553	Q9UP83
PDB IDs		2MPC 2WL1 4CG4
Enriched GO Terms of Interacting Partners?
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