SIVA1 and BAG5

		SIVA1	BAG5
Description		SIVA1 apoptosis inducing factor	BAG cochaperone 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleus Mitochondrion Cytosol Membrane Inclusion Body Perinuclear Region Of Cytoplasm
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor Receptor Binding CD27 Receptor Binding Protein Binding Metal Ion Binding	Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Chaperone Binding
	Biological Process	Viral Entry Into Host Cell Extrinsic Apoptotic Signaling Pathway	Protein Folding Golgi Organization Negative Regulation Of Neuron Projection Development Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Refolding Neuron Death Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways			Regulation of HSF1-mediated heat shock response
Drugs		Zinc
Diseases
GWAS		Endometrial cancer ( 27135401) Endometrial endometrioid carcinoma ( 27135401)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Broad depression or schizophrenia ( 30626913) Depression ( 29700475) Schizophrenia ( 25056061)
Interacting Genes		20 interacting genes: ABL2 APP BAG5 BCL2L1 BEX3 CD27 CD4 CDKN2A MEFV NEDD4 NEDD4L PCNA POLR2M PXMP2 RAD18 RHOU SSBP3 TCAP TNFRSF4 UBE2D1	18 interacting genes: ANXA3 ATP5MPL BANP CIRBP FAM118B HSPA4 IGHG4 JMJD6 KASH5 LRRK1 PINK1 PRKN SIVA1 SNCA STUB1 THAP1 TP53 TRIM27
Entrez ID		10572	9529
HPRD ID		16124	04862
Ensembl ID		ENSG00000184990	ENSG00000166170
Uniprot IDs		O15304	A0A024R6M6 Q9UL15
PDB IDs			2D9D 3A8Y
Enriched GO Terms of Interacting Partners?
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