MCM4 and ORC4

Number of citations of the paper that reports this interaction (PubMedID 12614612)
24

Data Source:
BioGRID (two hybrid)

		MCM4	ORC4
Description		minichromosome maintenance complex component 4	origin recognition complex subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Membrane MCM Complex	Nuclear Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytosol
	Molecular Function	DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Strand Elongation Involved In DNA Replication Mitotic DNA Replication Initiation	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases			Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Mean corpuscular volume ( 27863252) Red blood cell count ( 27863252)	Estimated glomerular filtration rate ( 31152163 31015462 30604766) Loneliness (MTAG) ( 29970889) Serum uric acid levels ( 30993211) Urate levels ( 31578528)
Interacting Genes		26 interacting genes: CCNA1 CDC5L CDC7 CDK1 CDK2 CDT1 DBF4 EP300 ESCO2 LIG4 MCM2 MCM3 MCM6 MCM7 MCM8 MCMBP ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RPA1 SSRP1 SUPT16H TLX2	28 interacting genes: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 H3-4 H4-16 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RDH5 RPA2 RRM2B TCF4
Entrez ID		4173	5000
HPRD ID		09094	09118
Ensembl ID		ENSG00000104738	ENSG00000115947
Uniprot IDs		B3KMX0 B4DLA6 P33991	A8K7H4 O43929 Q96B14
PDB IDs			5UJ7 5UJM
Enriched GO Terms of Interacting Partners?
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