ORC4 and MTUS1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ORC4	MTUS1
Description		origin recognition complex subunit 4	microtubule associated scaffold protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytosol	Extracellular Space Nucleus Nucleolus Cytoplasm Mitochondrion Golgi Apparatus Microtubule Organizing Center Spindle Microtubule Plasma Membrane Microtubule Cytoskeleton
	Molecular Function	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding	Microtubule Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation	Regulation Of Macrophage Chemotaxis
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Estimated glomerular filtration rate ( 31152163 31015462 30604766) Loneliness (MTAG) ( 29970889) Serum uric acid levels ( 30993211) Urate levels ( 31578528)	Hippocampal volume in normal cognition ( 29274321)
Interacting Genes		28 interacting genes: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 H3-4 H4-16 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RDH5 RPA2 RRM2B TCF4	3 interacting genes: AGTR2 FBXO7 ORC4
Entrez ID		5000	57509
HPRD ID		09118	11376
Ensembl ID		ENSG00000115947	ENSG00000129422
Uniprot IDs		A8K7H4 O43929 Q96B14	Q9ULD2
PDB IDs		5UJ7 5UJM
Enriched GO Terms of Interacting Partners?
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