MCM4 and TLX2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		MCM4	TLX2
Description		minichromosome maintenance complex component 4	T cell leukemia homeobox 2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Membrane MCM Complex	Nuclear Chromatin Cellular_component Cytoplasm
	Molecular Function	DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Strand Elongation Involved In DNA Replication Mitotic DNA Replication Initiation	Mesoderm Formation Positive Regulation Of Transcription By RNA Polymerase II Enteric Nervous System Development Negative Regulation Of Dendrite Morphogenesis
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Mean corpuscular volume ( 27863252) Red blood cell count ( 27863252)
Interacting Genes		26 interacting genes: CCNA1 CDC5L CDC7 CDK1 CDK2 CDT1 DBF4 EP300 ESCO2 LIG4 MCM2 MCM3 MCM6 MCM7 MCM8 MCMBP ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RPA1 SSRP1 SUPT16H TLX2	9 interacting genes: GTF2A1L IRF6 IRF9 MCM4 MEIS1 POU2F1 TLE1 YWHAH ZNF502
Entrez ID		4173	3196
HPRD ID		09094	07254
Ensembl ID		ENSG00000104738	ENSG00000115297
Uniprot IDs		B3KMX0 B4DLA6 P33991	O43763
PDB IDs			3A03
Enriched GO Terms of Interacting Partners?
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