ORC4 and RRM2B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ORC4	RRM2B
Description		origin recognition complex subunit 4	ribonucleotide reductase regulatory TP53 inducible subunit M2B
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GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytosol	Nucleoplasm Mitochondrion Cytosol
	Molecular Function	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation	Kidney Development Renal System Process Mitochondrial DNA Replication DNA Repair Response To Oxidative Stress Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process Response To Amine Nucleobase-containing Small Molecule Interconversion Oxidation-reduction Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes
Drugs			Cladribine
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome	Mitochondrial DNA depletion syndrome (MDS)
GWAS		Estimated glomerular filtration rate ( 31152163 31015462 30604766) Loneliness (MTAG) ( 29970889) Serum uric acid levels ( 30993211) Urate levels ( 31578528)	Blood protein levels ( 30072576 29875488) Chromosomal aberration frequency (total) ( 31586183) Chronic obstructive pulmonary disease ( 28166215) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010)
Interacting Genes		28 interacting genes: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 H3-4 H4-16 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RDH5 RPA2 RRM2B TCF4	8 interacting genes: CDKN1A MDM2 ORC4 RNF41 RRM1 RRM2 SRPK2 TP53
Entrez ID		5000	50484
HPRD ID		09118	05276
Ensembl ID		ENSG00000115947	ENSG00000048392
Uniprot IDs		A8K7H4 O43929 Q96B14	Q7LG56
PDB IDs		5UJ7 5UJM	2VUX 3HF1 4DJN
Enriched GO Terms of Interacting Partners?
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