KRT5 and KRT1

Number of citations of the paper that reports this interaction (PubMedID 11591653)
41

Data Source:
HPRD (in vivo)

		KRT5	KRT1
Description		keratin 5	keratin 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Plasma Membrane Membrane Keratin Filament Extracellular Exosome	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Membrane Keratin Filament Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Scaffold Protein Binding	Protein Binding Carbohydrate Binding Structural Constituent Of Epidermis Signaling Receptor Activity Protein Heterodimerization Activity
	Biological Process	Cytoskeleton Organization Epidermis Development Keratinization Hemidesmosome Assembly Cornification	Complement Activation, Lectin Pathway Retina Homeostasis Response To Oxidative Stress Peptide Cross-linking Keratinization Fibrinolysis Neutrophil Degranulation Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Protein Heterotetramerization Establishment Of Skin Barrier Cornification
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope	Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs		Zinc	Zinc Copper
Diseases		Dowling-Degos disease Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic	Epidermolytic palmoplantar keratoderma (EPPK) Ichthyosis hystrix, Curth-Macklin type Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE) Striate palmoplantar keratoderma
GWAS		Basal cell carcinoma ( 31174203 24403052 25855136 27539887) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)
Interacting Genes		17 interacting genes: ALOX12 ALOX12B APC DSP DST EVPL KIFC3 KRT1 KRT14 KRT15 KRT18 KRT31 KRT38 KRT40 PKP2 TCHP UBE3A	21 interacting genes: CALB2 CSTA DSP EVPL F12 FANCA FANCC IVL KNG1 KRT15 KRT33B KRT5 LINC00839 LORICRIN MBL2 NINL PDE4DIP PI3 PRKCE UBE3A YWHAQ
Entrez ID		3852	3848
HPRD ID		01010	00763
Ensembl ID		ENSG00000186081	ENSG00000167768
Uniprot IDs		P13647	P04264
PDB IDs		3TNU	4ZRY 6E2J 6UUI
Enriched GO Terms of Interacting Partners?
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