KRT1 and PI3

Number of citations of the paper that reports this interaction (PubMedID 8999895)
28

Data Source:
BioGRID (pull down)

		KRT1	PI3
Description		keratin 1	peptidase inhibitor 3
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Membrane Keratin Filament Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Cornified Envelope Extracellular Region Cytosol Extracellular Matrix
	Molecular Function	Protein Binding Carbohydrate Binding Structural Constituent Of Epidermis Signaling Receptor Activity Protein Heterodimerization Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Structural Constituent Of Epidermis
	Biological Process	Complement Activation, Lectin Pathway Retina Homeostasis Response To Oxidative Stress Peptide Cross-linking Keratinization Fibrinolysis Neutrophil Degranulation Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Protein Heterotetramerization Establishment Of Skin Barrier Cornification	Copulation Negative Regulation Of Endopeptidase Activity Peptide Cross-linking Antimicrobial Humoral Response Cornification
Pathways		Neutrophil degranulation Keratinization Formation of the cornified envelope	Antimicrobial peptides Formation of the cornified envelope
Drugs		Zinc Copper
Diseases		Epidermolytic palmoplantar keratoderma (EPPK) Ichthyosis hystrix, Curth-Macklin type Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE) Striate palmoplantar keratoderma
GWAS			Bipolar disorder ( 31043756) Blood protein levels ( 30072576 29875488 28240269)
Interacting Genes		21 interacting genes: CALB2 CSTA DSP EVPL F12 FANCA FANCC IVL KNG1 KRT15 KRT33B KRT5 LINC00839 LORICRIN MBL2 NINL PDE4DIP PI3 PRKCE UBE3A YWHAQ	5 interacting genes: CELA1 CSTA EVPL KRT1 LORICRIN
Entrez ID		3848	5266
HPRD ID		00763	15947
Ensembl ID		ENSG00000167768	ENSG00000124102
Uniprot IDs		P04264	P19957
PDB IDs		4ZRY 6E2J 6UUI	1FLE 2REL 6ATU
Enriched GO Terms of Interacting Partners?
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