APLP1 and TMSB4X

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		APLP1	TMSB4X
Description		amyloid beta precursor like protein 1	thymosin beta 4 X-linked
Image
GO Annotations	Cellular Component	Basement Membrane Plasma Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Cell Nucleus Cytoplasm Cytosol Cytoskeleton Platelet Alpha Granule Lumen
	Molecular Function	Protein Binding Heparin Binding Alpha-2A Adrenergic Receptor Binding Alpha-2B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Identical Protein Binding Transition Metal Ion Binding	RNA Binding Actin Monomer Binding Protein Binding Enzyme Binding
	Biological Process	Endocytosis Apoptotic Process Cell Adhesion Nervous System Development Animal Organ Morphogenesis Cellular Response To Norepinephrine Stimulus Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway	Platelet Degranulation Actin Filament Organization Cytoplasmic Sequestering Of NF-kappaB Regulation Of Cell Migration Negative Regulation Of NF-kappaB Transcription Factor Activity Tumor Necrosis Factor-mediated Signaling Pathway Sequestering Of Actin Monomers Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Inflammatory Response Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proton-transporting ATP Synthase Activity, Rotational Mechanism Negative Regulation Of Interleukin-8 Secretion Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of ATP Biosynthetic Process
Pathways			Platelet degranulation
Drugs		Zinc Copper
Diseases
GWAS		Severe influenza A (H1N1) infection ( 26379185)	Asthma ( 30929738) Asthma (childhood onset) ( 30929738)
Interacting Genes		42 interacting genes: ANXA7 APBB1 CDK4 CDKN1A CDKN2C CRCT1 CSNK2B DAB1 DAB2 EEF1A1 EIF2S2 GDF9 GSTM4 HAP1 HLA-DQA1 HSPE1 ING5 KAT5 LRIF1 MPHOSPH6 NACA PCDHA4 PHF10 PIN1 PNP PRNP RAP1B RBM48 RCC1 SAT1 SETDB1 SMN1 SNCA STX5 TCF21 TK1 TMSB4X TOE1 TSC22D1 UTP14A VIM ZNF24	29 interacting genes: ACTA1 ACTA2 ACTB ACTG1 ALAS1 ANXA7 APLP1 CDKN1A FAM118B GRB7 IGSF21 ILK KRT13 KRT15 KRT31 KRT40 LIMS1 PNMA1 PPP4C RAD21 RBPMS SCHIP1 SMN1 TAF1D TGM2 TK1 TRIM23 TRIM27 TRIP6
Entrez ID		333	7114
HPRD ID		00102	02153
Ensembl ID		ENSG00000105290	ENSG00000205542
Uniprot IDs		P51693	A2VCK8 P62328 Q0P5T0
PDB IDs		3PMR 3Q7G 3Q7L 3QMK 4RD9 4RDA	1UY5 3TU5 4PL7 4PL8
Enriched GO Terms of Interacting Partners?
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