TMSB4X and ACTA1

Number of citations of the paper that reports this interaction (PubMedID 11812134)
16

Data Source:
HPRD (in vitro)

		TMSB4X	ACTA1
Description		thymosin beta 4 X-linked	actin alpha 1, skeletal muscle
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cell Nucleus Cytoplasm Cytosol Cytoskeleton Platelet Alpha Granule Lumen	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle
	Molecular Function	RNA Binding Actin Monomer Binding Protein Binding Enzyme Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding
	Biological Process	Platelet Degranulation Actin Filament Organization Cytoplasmic Sequestering Of NF-kappaB Regulation Of Cell Migration Negative Regulation Of NF-kappaB Transcription Factor Activity Tumor Necrosis Factor-mediated Signaling Pathway Sequestering Of Actin Monomers Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Inflammatory Response Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proton-transporting ATP Synthase Activity, Rotational Mechanism Negative Regulation Of Interleukin-8 Secretion Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of ATP Biosynthetic Process	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Positive Regulation Of Gene Expression Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development Cellular Response To Organonitrogen Compound Mesenchyme Migration
Pathways		Platelet degranulation	Striated Muscle Contraction
Drugs			Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 4-Methyl-Histidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B LATRUNCULIN B
Diseases			Congenital fiber type disproportion (CFTD) Cap myopathy Nemaline myopathy
GWAS		Asthma ( 30929738) Asthma (childhood onset) ( 30929738)
Interacting Genes		29 interacting genes: ACTA1 ACTA2 ACTB ACTG1 ALAS1 ANXA7 APLP1 CDKN1A FAM118B GRB7 IGSF21 ILK KRT13 KRT15 KRT31 KRT40 LIMS1 PNMA1 PPP4C RAD21 RBPMS SCHIP1 SMN1 TAF1D TGM2 TK1 TRIM23 TRIM27 TRIP6	112 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		7114	58
HPRD ID		02153	00030
Ensembl ID		ENSG00000205542	ENSG00000143632
Uniprot IDs		A2VCK8 P62328 Q0P5T0	P68133
PDB IDs		1UY5 3TU5 4PL7 4PL8
Enriched GO Terms of Interacting Partners?
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