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APEX1 and HMGB2
Number of citations of the paper that reports this interaction (PubMedID
12524539
)
67
Data Source:
HPRD
(in vitro)
APEX1
HMGB2
Description
apurinic/apyrimidinic endodeoxyribonuclease 1
high mobility group box 2
Image
No pdb structure
GO Annotations
Cellular Component
Nuclear Chromosome, Telomeric Region
Cell
Nucleus
Nucleoplasm
Transcription Factor Complex
Nucleolus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Centrosome
Ribosome
Nuclear Speck
Perinuclear Region Of Cytoplasm
Nuclear Chromatin
Condensed Chromosome
Extracellular Space
Cell
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Molecular Function
DNA Binding
Damaged DNA Binding
Double-stranded Telomeric DNA Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
Endonuclease Activity
Endodeoxyribonuclease Activity
RNA-DNA Hybrid Ribonuclease Activity
Phosphodiesterase I Activity
Uracil DNA N-glycosylase Activity
Protein Binding
Phosphoric Diester Hydrolase Activity
Double-stranded DNA Exodeoxyribonuclease Activity
Double-stranded DNA 3'-5' Exodeoxyribonuclease Activity
3'-5' Exonuclease Activity
Oxidoreductase Activity
Site-specific Endodeoxyribonuclease Activity, Specific For Altered Base
Chromatin DNA Binding
Protein-containing Complex Binding
Metal Ion Binding
NF-kappaB Binding
Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
Four-way Junction DNA Binding
Proximal Promoter Sequence-specific DNA Binding
DNA Binding
Damaged DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Transcription Coactivator Activity
RNA Binding
Protein Binding
Transcription Factor Binding
Drug Binding
DNA Binding, Bending
Protein Domain Specific Binding
Chemoattractant Activity
Transcription Regulatory Region DNA Binding
Non-sequence-specific DNA Binding, Bending
RAGE Receptor Binding
Supercoiled DNA Binding
Biological Process
Telomere Maintenance
DNA Repair
Base-excision Repair
Base-excision Repair, Base-free Sugar-phosphate Removal
DNA Recombination
Aging
Negative Regulation Of Smooth Muscle Cell Migration
Regulation Of Apoptotic Process
Regulation Of MRNA Stability
Cell Redox Homeostasis
Oxidation-reduction Process
Cellular Response To Hydrogen Peroxide
Cellular Response To CAMP
Cellular Response To Peptide Hormone Stimulus
DNA Demethylation
RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Telomere Maintenance Via Base-excision Repair
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Endothelial Cell Proliferation
Inflammatory Response To Antigenic Stimulus
DNA Topological Change
Apoptotic DNA Fragmentation
DNA Recombination
Chromatin Organization
Nucleosome Assembly
Chromatin Remodeling
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Spermatid Nucleus Differentiation
Male Gonad Development
Positive Regulation Of Nuclease Activity
DNA Geometric Change
Response To Lipopolysaccharide
Positive Regulation Of Interferon-beta Production
V(D)J Recombination
Response To Drug
Positive Regulation Of DNA Binding
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Response To Steroid Hormone
Regulation Of Neurogenesis
Defense Response To Gram-negative Bacterium
Defense Response To Gram-positive Bacterium
Positive Chemotaxis
DNA Ligation Involved In DNA Repair
Cell Chemotaxis
Cellular Response To Lipopolysaccharide
Regulation Of Stem Cell Proliferation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways
Displacement of DNA glycosylase by APEX1
POLB-Dependent Long Patch Base Excision Repair
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
PCNA-Dependent Long Patch Base Excision Repair
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
Resolution of Abasic Sites (AP sites)
Apoptosis induced DNA fragmentation
Drugs
Lucanthone
Diseases
GWAS
Menopause (age at onset) (
26414677
)
Interacting Genes
41 interacting genes:
ANP32A
ANP32C
APP
CSNK2A1
DCTN1
EP300
FBXO7
FEN1
GZMA
GZMK
HDAC1
HIF1A
HMGA1
HMGA2
HMGB2
HNRNPL
HOXC13
HSPA1A
MCL1
MDM2
MUTYH
NME1
NUDT3
NXF2
PCNA
POLB
POLR3D
SET
SRPK1
SRPK2
TCF21
TERF1
TERF2
TERF2IP
TP53
TXN
UBE2I
UBR3
XRCC1
XRCC5
XRCC6
37 interacting genes:
APEX1
APP
AR
ARCN1
C1QBP
CACTIN
CHAF1A
CREBBP
CSNK1A1
EIF1
FBXO7
GZMA
GZMK
H3-3A
HACD3
HDLBP
HMGA1
LZTS1
MIEN1
NAP1L1
NCBP3
NEXN
NR3C1
PGR
PKNOX1
POU2F1
POU2F2
POU3F1
POU5F1
PRKDC
RAG1
SAMM50
SET
TP53
ZNF428
ZNF622
ZNF668
Entrez ID
328
3148
HPRD ID
00136
01229
Ensembl ID
ENSG00000100823
ENSG00000164104
Uniprot IDs
P27695
Q5TZP7
P26583
PDB IDs
1BIX
1CQG
1CQH
1DE8
1DE9
1DEW
1E9N
1HD7
2ISI
2O3H
3U8U
4IEM
4LND
4QH9
4QHD
4QHE
5CFG
5DFF
5DFH
5DFI
5DFJ
5DG0
5WN0
5WN1
5WN2
5WN3
5WN4
5WN5
6BOQ
6BOR
6BOS
6BOT
6BOU
6BOV
6BOW
6MK3
6MKK
6MKM
6MKO
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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