HMGB2 and MIEN1

Number of citations of the paper that reports this interaction (PubMedID 29721183)
2

Data Source:
BioGRID (two hybrid)

		HMGB2	MIEN1
Description		high mobility group box 2	migration and invasion enhancer 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Condensed Chromosome Extracellular Space Cell Nucleus Nucleoplasm Nucleolus Cytoplasm Protein-containing Complex Perinuclear Region Of Cytoplasm	Cytosol Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane
	Molecular Function	Four-way Junction DNA Binding Proximal Promoter Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding Drug Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Transcription Regulatory Region DNA Binding Non-sequence-specific DNA Binding, Bending RAGE Receptor Binding Supercoiled DNA Binding	Protein Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Inflammatory Response To Antigenic Stimulus DNA Topological Change Apoptotic DNA Fragmentation DNA Recombination Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Spermatid Nucleus Differentiation Male Gonad Development Positive Regulation Of Nuclease Activity DNA Geometric Change Response To Lipopolysaccharide Positive Regulation Of Interferon-beta Production V(D)J Recombination Response To Drug Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis DNA Ligation Involved In DNA Repair Cell Chemotaxis Cellular Response To Lipopolysaccharide Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Apoptotic Process Positive Regulation Of Cell Migration Negative Regulation Of Apoptotic Process Positive Regulation Of Filopodium Assembly
Pathways		Apoptosis induced DNA fragmentation
Drugs
Diseases
GWAS			Asthma ( 31619474 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Systemic lupus erythematosus ( 28714469)
Interacting Genes		37 interacting genes: APEX1 APP AR ARCN1 C1QBP CACTIN CHAF1A CREBBP CSNK1A1 EIF1 FBXO7 GZMA GZMK H3-3A HACD3 HDLBP HMGA1 LZTS1 MIEN1 NAP1L1 NCBP3 NEXN NR3C1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 SAMM50 SET TP53 ZNF428 ZNF622 ZNF668	3 interacting genes: HMGB2 NLGN3 REL
Entrez ID		3148	84299
HPRD ID		01229	12681
Ensembl ID		ENSG00000164104	ENSG00000141741
Uniprot IDs		P26583	J3KTI2 Q9BRT3
PDB IDs			2LJK
Enriched GO Terms of Interacting Partners?
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