APEX1 and FEN1

Number of citations of the paper that reports this interaction (PubMedID 11601988)
47

Data Source:
HPRD (in vitro, in vivo)

		APEX1	FEN1
Description		apurinic/apyrimidinic endodeoxyribonuclease 1	flap structure-specific endonuclease 1
Image
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Cell Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Ribosome Nuclear Speck Perinuclear Region Of Cytoplasm	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane Protein-containing Complex
	Molecular Function	DNA Binding Damaged DNA Binding Double-stranded Telomeric DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endonuclease Activity Endodeoxyribonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Phosphodiesterase I Activity Uracil DNA N-glycosylase Activity Protein Binding Phosphoric Diester Hydrolase Activity Double-stranded DNA Exodeoxyribonuclease Activity Double-stranded DNA 3'-5' Exodeoxyribonuclease Activity 3'-5' Exonuclease Activity Oxidoreductase Activity Site-specific Endodeoxyribonuclease Activity, Specific For Altered Base Chromatin DNA Binding Protein-containing Complex Binding Metal Ion Binding NF-kappaB Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity	Magnesium Ion Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding Double-stranded DNA Exodeoxyribonuclease Activity 5'-3' Exonuclease Activity 5'-flap Endonuclease Activity Manganese Ion Binding Flap Endonuclease Activity
	Biological Process	Telomere Maintenance DNA Repair Base-excision Repair Base-excision Repair, Base-free Sugar-phosphate Removal DNA Recombination Aging Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Apoptotic Process Regulation Of MRNA Stability Cell Redox Homeostasis Oxidation-reduction Process Cellular Response To Hydrogen Peroxide Cellular Response To CAMP Cellular Response To Peptide Hormone Stimulus DNA Demethylation RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Telomere Maintenance Via Base-excision Repair Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Nucleic Acid-templated Transcription	Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Base-excision Repair Double-strand Break Repair Memory UV Protection Telomere Maintenance Via Semi-conservative Replication DNA Replication, Removal Of RNA Primer Positive Regulation Of Sister Chromatid Cohesion Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		Displacement of DNA glycosylase by APEX1 POLB-Dependent Long Patch Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway PCNA-Dependent Long Patch Base Excision Repair Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)	POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Removal of the Flap Intermediate from the C-strand PCNA-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) Removal of the Flap Intermediate
Drugs		Lucanthone	Iron
Diseases
GWAS		Menopause (age at onset) ( 26414677)	Asthma ( 31619474) Bipolar disorder ( 28115744 31043756) Bipolar I disorder ( 31043756) Colorectal cancer ( 24836286) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 28067908) Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Laryngeal squamous cell carcinoma ( 25194280) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483 23378610) Oleic acid (18:1n-9) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 23362303) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Platelet count ( 22139419) Red blood cell fatty acid levels ( 25500335) Resting heart rate ( 27798624) Serum metabolite levels ( 23093944) Serum metabolite ratios in chronic kidney disease ( 29545352) Stearic acid (18:0) levels ( 23362303)
Interacting Genes		41 interacting genes: ANP32A ANP32C APP CSNK2A1 DCTN1 EP300 FBXO7 FEN1 GZMA GZMK HDAC1 HIF1A HMGA1 HMGA2 HMGB2 HNRNPL HOXC13 HSPA1A MCL1 MDM2 MUTYH NME1 NUDT3 NXF2 PCNA POLB POLR3D SET SRPK1 SRPK2 TCF21 TERF1 TERF2 TERF2IP TP53 TXN UBE2I UBR3 XRCC1 XRCC5 XRCC6	18 interacting genes: APEX1 APP ARHGDIA BLM CCNA2 CDK1 CDK2 EEF1G EP300 GSK3B HNRNPA1 HUS1 PCNA RAD1 RAD9A TERF1 WDR4 WRN
Entrez ID		328	2237
HPRD ID		00136	02670
Ensembl ID		ENSG00000100823	ENSG00000168496
Uniprot IDs		P27695 Q5TZP7	P39748 Q6FHX6
PDB IDs		1BIX 1CQG 1CQH 1DE8 1DE9 1DEW 1E9N 1HD7 2ISI 2O3H 3U8U 4IEM 4LND 4QH9 4QHD 4QHE 5CFG 5DFF 5DFH 5DFI 5DFJ 5DG0 5WN0 5WN1 5WN2 5WN3 5WN4 5WN5 6BOQ 6BOR 6BOS 6BOT 6BOU 6BOV 6BOW 6MK3 6MKK 6MKM 6MKO	1U7B 1UL1 3Q8K 3Q8L 3Q8M 3UVU 5E0V 5FV7 5K97 5KSE 5UM9 5ZOD 5ZOE 5ZOF 5ZOG
Enriched GO Terms of Interacting Partners?
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