APEX1 and NUDT3

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		APEX1	NUDT3
Description		apurinic/apyrimidinic endodeoxyribonuclease 1	nudix hydrolase 3
Image
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Cell Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Ribosome Nuclear Speck Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol
	Molecular Function	DNA Binding Damaged DNA Binding Double-stranded Telomeric DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endonuclease Activity Endodeoxyribonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Phosphodiesterase I Activity Uracil DNA N-glycosylase Activity Protein Binding Phosphoric Diester Hydrolase Activity Double-stranded DNA Exodeoxyribonuclease Activity Double-stranded DNA 3'-5' Exodeoxyribonuclease Activity 3'-5' Exonuclease Activity Oxidoreductase Activity Site-specific Endodeoxyribonuclease Activity, Specific For Altered Base Chromatin DNA Binding Protein-containing Complex Binding Metal Ion Binding NF-kappaB Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity	Magnesium Ion Binding Endopolyphosphatase Activity Diphosphoinositol-polyphosphate Diphosphatase Activity Bis(5'-adenosyl)-hexaphosphatase Activity Bis(5'-adenosyl)-pentaphosphatase Activity M7G(5')pppN Diphosphatase Activity Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity
	Biological Process	Telomere Maintenance DNA Repair Base-excision Repair Base-excision Repair, Base-free Sugar-phosphate Removal DNA Recombination Aging Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Apoptotic Process Regulation Of MRNA Stability Cell Redox Homeostasis Oxidation-reduction Process Cellular Response To Hydrogen Peroxide Cellular Response To CAMP Cellular Response To Peptide Hormone Stimulus DNA Demethylation RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Telomere Maintenance Via Base-excision Repair Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Nucleic Acid-templated Transcription	Cell-cell Signaling Diadenosine Polyphosphate Catabolic Process Inositol Phosphate Metabolic Process Diphosphoinositol Polyphosphate Metabolic Process Diphosphoinositol Polyphosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Diadenosine Hexaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process
Pathways		Displacement of DNA glycosylase by APEX1 POLB-Dependent Long Patch Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway PCNA-Dependent Long Patch Base Excision Repair Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)	Synthesis of pyrophosphates in the cytosol
Drugs		Lucanthone
Diseases
GWAS		Menopause (age at onset) ( 26414677)	Atrial fibrillation ( 29892015) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 20935630) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 30604766) Height ( 25429064 19893584 31562340) Hip circumference ( 25673412)
Interacting Genes		41 interacting genes: ANP32A ANP32C APP CSNK2A1 DCTN1 EP300 FBXO7 FEN1 GZMA GZMK HDAC1 HIF1A HMGA1 HMGA2 HMGB2 HNRNPL HOXC13 HSPA1A MCL1 MDM2 MUTYH NME1 NUDT3 NXF2 PCNA POLB POLR3D SET SRPK1 SRPK2 TCF21 TERF1 TERF2 TERF2IP TP53 TXN UBE2I UBR3 XRCC1 XRCC5 XRCC6	36 interacting genes: ALAS1 APEX1 ARL6IP1 ASB13 CCL11 CHCHD3 DBN1 DDR1 DNAJA1 EEF1G FXYD3 HES1 ITFG1 MAF1 MCM5 MEX3B NR2C1 NUDT5 OAT PDCD5 PEX5 PRKD3 RAB17 REEP5 RNF126 RPL17 RPL8 RPLP1 SOX30 TNNT3 TUBA1A TUBGCP4 UBR1 VPS51 WDR74 XPNPEP1
Entrez ID		328	11165
HPRD ID		00136	14849
Ensembl ID		ENSG00000100823	ENSG00000272325
Uniprot IDs		P27695 Q5TZP7	O95989
PDB IDs		1BIX 1CQG 1CQH 1DE8 1DE9 1DEW 1E9N 1HD7 2ISI 2O3H 3U8U 4IEM 4LND 4QH9 4QHD 4QHE 5CFG 5DFF 5DFH 5DFI 5DFJ 5DG0 5WN0 5WN1 5WN2 5WN3 5WN4 5WN5 6BOQ 6BOR 6BOS 6BOT 6BOU 6BOV 6BOW 6MK3 6MKK 6MKM 6MKO	2FVV 2Q9P
Enriched GO Terms of Interacting Partners?
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