SOX8 and NR5A1

Number of citations of the paper that reports this interaction (PubMedID 12732652)
38

Data Source:
HPRD (in vitro)

		SOX8	NR5A1
Description		SRY-box transcription factor 8	nuclear receptor subfamily 5 group A member 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytoplasm Nuclear Transcription Factor Complex	Nuclear Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Transcription Factor Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Steroid Hormone Receptor Activity Transcription Coactivator Activity Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Enzyme Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation In Utero Embryonic Development Neural Crest Cell Migration Morphogenesis Of An Epithelium Signal Transduction Spermatogenesis Peripheral Nervous System Development Male Gonad Development Regulation Of Hormone Levels Positive Regulation Of Gliogenesis Neural Crest Cell Development Positive Regulation Of Osteoblast Proliferation Skeletal Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Photoreceptor Cell Differentiation Cell Maturation Enteric Nervous System Development Oligodendrocyte Differentiation Sertoli Cell Development Astrocyte Fate Commitment Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Adipose Tissue Development Morphogenesis Of A Branching Epithelium Renal Vesicle Induction Ureter Morphogenesis Metanephric Nephron Tubule Formation Positive Regulation Of Kidney Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis	Luteinization Transcription Initiation From RNA Polymerase II Promoter Sex Determination Primary Sex Determination Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Tissue Development Multicellular Organism Aging Positive Regulation Of Gene Expression Cell Differentiation Male Sex Determination Adrenal Gland Development Intracellular Receptor Signaling Pathway Hormone Metabolic Process Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Location In Nucleus Response To Gonadotropin-releasing Hormone Calcineurin-mediated Signaling Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development
Pathways			Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Transcriptional regulation of pluripotent stem cells
Drugs			(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE Phosphatidyl ethanol
Diseases			Premature ovarian failure 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Logical memory (immediate recall) in normal cognition ( 29274321) Multiple sclerosis ( 31604244 21833088) Polycystic ovary syndrome ( 25574032)	Chronotype ( 30696823)
Interacting Genes		18 interacting genes: CEBPA DLX5 EGR2 HHEX HOXC11 JAM2 JUN MMP1 NOD1 NR5A1 OLIG2 PAX3 PIDD1 POU3F3 POU5F1 SP1 TCF12 UTF1	31 interacting genes: AR CREBBP CTNNB1 CXXC1 EDF1 GATA4 GTF2B JUN MAPK1 NCK2 NCOA1 NFKB2 NFYA NR0B1 NRIP1 PIAS1 PITX1 PNRC2 PROX1 RAB14 RAD54L2 SMARCD3 SOX2 SOX8 SOX9 SP1 TBX19 TRAPPC2 TRERF1 UBE2I ZNF653
Entrez ID		30812	2516
HPRD ID		16175	01702
Ensembl ID		ENSG00000005513	ENSG00000136931
Uniprot IDs		P57073	F1D8R8 Q13285
PDB IDs			1YOW 1ZDT 4QJR 4QK4
Enriched GO Terms of Interacting Partners?
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