NR5A1 and CXXC1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		NR5A1	CXXC1
Description		nuclear receptor subfamily 5 group A member 1	CXXC finger protein 1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Factor Complex	Nucleus Nucleoplasm Cytosol Nuclear Matrix Nuclear Speck Histone Methyltransferase Complex Set1C/COMPASS Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Steroid Hormone Receptor Activity Transcription Coactivator Activity Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Enzyme Binding Sequence-specific DNA Binding	Proximal Promoter Sequence-specific DNA Binding Protein Binding Zinc Ion Binding Methylated Histone Binding Histone Methyltransferase Activity (H3-K4 Specific) Unmethylated CpG Binding
	Biological Process	Luteinization Transcription Initiation From RNA Polymerase II Promoter Sex Determination Primary Sex Determination Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Tissue Development Multicellular Organism Aging Positive Regulation Of Gene Expression Cell Differentiation Male Sex Determination Adrenal Gland Development Intracellular Receptor Signaling Pathway Hormone Metabolic Process Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Location In Nucleus Response To Gonadotropin-releasing Hormone Calcineurin-mediated Signaling Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Regulation Of Transcription, DNA-templated IRE1-mediated Unfolded Protein Response Positive Regulation Of Transcription, DNA-templated Histone H3-K4 Methylation
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Transcriptional regulation of pluripotent stem cells	XBP1(S) activates chaperone genes
Drugs		(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE Phosphatidyl ethanol
Diseases		Premature ovarian failure 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Chronotype ( 30696823)	Chronic lymphocytic leukemia ( 28165464)
Interacting Genes		31 interacting genes: AR CREBBP CTNNB1 CXXC1 EDF1 GATA4 GTF2B JUN MAPK1 NCK2 NCOA1 NFKB2 NFYA NR0B1 NRIP1 PIAS1 PITX1 PNRC2 PROX1 RAB14 RAD54L2 SMARCD3 SOX2 SOX8 SOX9 SP1 TBX19 TRAPPC2 TRERF1 UBE2I ZNF653	8 interacting genes: EP300 MEOX2 NR5A1 PPP1CA SMURF1 TAX1BP1 TBP TP53
Entrez ID		2516	30827
HPRD ID		01702	10852
Ensembl ID		ENSG00000136931	ENSG00000154832
Uniprot IDs		F1D8R8 Q13285	Q9P0U4
PDB IDs		1YOW 1ZDT 4QJR 4QK4	3QMB 3QMC 3QMD 3QMG 3QMH 3QMI
Enriched GO Terms of Interacting Partners?
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