NR5A1 and TBX19

Number of citations of the paper that reports this interaction (PubMedID 12651892)
57

Data Source:
HPRD (in vitro)

		NR5A1	TBX19
Description		nuclear receptor subfamily 5 group A member 1	T-box transcription factor 19
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Factor Complex	Nuclear Chromatin Nucleus
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Steroid Hormone Receptor Activity Transcription Coactivator Activity Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Enzyme Binding Sequence-specific DNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
	Biological Process	Luteinization Transcription Initiation From RNA Polymerase II Promoter Sex Determination Primary Sex Determination Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Tissue Development Multicellular Organism Aging Positive Regulation Of Gene Expression Cell Differentiation Male Sex Determination Adrenal Gland Development Intracellular Receptor Signaling Pathway Hormone Metabolic Process Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Location In Nucleus Response To Gonadotropin-releasing Hormone Calcineurin-mediated Signaling Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Negative Regulation Of Transcription By RNA Polymerase II Mesoderm Formation Cell Fate Specification Somitogenesis Heart Morphogenesis Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Pituitary Gland Development Regulation Of Cell Proliferation Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Transcriptional regulation of pluripotent stem cells
Drugs		(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE Phosphatidyl ethanol
Diseases		Premature ovarian failure 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD	Adrenocorticotropic hormone deficiency; Isolated ACDH deficiency (IAD)
GWAS		Chronotype ( 30696823)
Interacting Genes		31 interacting genes: AR CREBBP CTNNB1 CXXC1 EDF1 GATA4 GTF2B JUN MAPK1 NCK2 NCOA1 NFKB2 NFYA NR0B1 NRIP1 PIAS1 PITX1 PNRC2 PROX1 RAB14 RAD54L2 SMARCD3 SOX2 SOX8 SOX9 SP1 TBX19 TRAPPC2 TRERF1 UBE2I ZNF653	1 interacting genes: NR5A1
Entrez ID		2516	9095
HPRD ID		01702	05214
Ensembl ID		ENSG00000136931	ENSG00000143178
Uniprot IDs		F1D8R8 Q13285	B3KRD9 O60806
PDB IDs		1YOW 1ZDT 4QJR 4QK4
Enriched GO Terms of Interacting Partners?
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