ANXA4 and SMPD1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		ANXA4	SMPD1
Description		annexin A4	sphingomyelin phosphodiesterase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Vesicle Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Space Lysosome Endosome Plasma Membrane Lamellar Body Lysosomal Lumen Extracellular Exosome
	Molecular Function	Phospholipase Inhibitor Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Identical Protein Binding Calcium-dependent Protein Binding NF-kappaB Binding	Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity, Acting On Glycosyl Bonds Acid Sphingomyelin Phosphodiesterase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Signal Transduction Epithelial Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Interleukin-8 Secretion	Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Signal Transduction Nervous System Development Cholesterol Metabolic Process Termination Of Signal Transduction Positive Regulation Of Protein Dephosphorylation Response To Cocaine Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Ceramide Biosynthetic Process
Pathways			Glycosphingolipid metabolism
Drugs		Copper	Amlodipine Chlorpromazine Desipramine
Diseases			Niemann-Pick disease (NPD), including;; Niemann-Pick disease, type A; Niemann-Pick disease, type B
GWAS		Atrial fibrillation ( 28416818 30061737) Palmitoleic acid (16:1n-7) levels ( 23362303)	Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		8 interacting genes: GP2 NMT2 PADI4 POT1 RHOU SMPD1 TINF2 UCHL5	6 interacting genes: ANXA4 ANXA7 ASAH1 BEX3 DUSP23 NR1H2
Entrez ID		307	6609
HPRD ID		00112	06353
Ensembl ID		ENSG00000196975	ENSG00000166311
Uniprot IDs		P09525 Q6LES2 Q6P452	E9LUE8 E9LUE9 P17405 Q59EN6 Q8IUN0
PDB IDs		2ZOC	5I81 5I85 5I8R 5JG8
Enriched GO Terms of Interacting Partners?
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