ANXA4 and PADI4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ANXA4	PADI4
Description		annexin A4	peptidyl arginine deiminase 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Vesicle Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Phospholipase Inhibitor Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Identical Protein Binding Calcium-dependent Protein Binding NF-kappaB Binding	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Arginine Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Signal Transduction Epithelial Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Interleukin-8 Secretion	Chromatin Organization Nucleosome Assembly Chromatin Remodeling Cellular Protein Modification Process Protein Citrullination Stem Cell Population Maintenance Histone H3-R26 Citrullination Histone Citrullination Innate Immune Response
Pathways			Chromatin modifying enzymes
Drugs		Copper	L-Citrulline Azithromycin Doxycycline Tetracycline Streptomycin N-[(1S)-1-(AMINOCARBONYL)-4-(ETHANIMIDOYLAMINO)BUTYL]BENZAMIDE
Diseases
GWAS		Atrial fibrillation ( 28416818 30061737) Palmitoleic acid (16:1n-7) levels ( 23362303)	Basal cell carcinoma ( 18849993) IgA nephropathy ( 25305756) Rheumatoid arthritis ( 21452313 21505073 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		8 interacting genes: GP2 NMT2 PADI4 POT1 RHOU SMPD1 TINF2 UCHL5	8 interacting genes: ANXA4 APP FBXO25 H3C15 HDAC2 LRRK2 NPM1 SMURF1
Entrez ID		307	23569
HPRD ID		00112	05635
Ensembl ID		ENSG00000196975	ENSG00000159339
Uniprot IDs		P09525 Q6LES2 Q6P452	Q9UM07
PDB IDs		2ZOC	1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT 4X8C 4X8G 5N0M 5N0Y 5N0Z 5N1B
Enriched GO Terms of Interacting Partners?
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