SMPD1 and ANXA7

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		SMPD1	ANXA7
Description		sphingomyelin phosphodiesterase 1	annexin A7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Lysosome Endosome Plasma Membrane Lamellar Body Lysosomal Lumen Extracellular Exosome	Cell Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Chromaffin Granule Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity, Acting On Glycosyl Bonds Acid Sphingomyelin Phosphodiesterase Activity	RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Calcium-dependent Protein Binding
	Biological Process	Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Signal Transduction Nervous System Development Cholesterol Metabolic Process Termination Of Signal Transduction Positive Regulation Of Protein Dephosphorylation Response To Cocaine Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Ceramide Biosynthetic Process	Autophagy Hemostasis Cell Proliferation Regulation Of Cell Shape Response To Salt Stress Cellular Water Homeostasis Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Epithelial Cell Differentiation Membrane Fusion
Pathways		Glycosphingolipid metabolism
Drugs		Amlodipine Chlorpromazine Desipramine
Diseases		Niemann-Pick disease (NPD), including;; Niemann-Pick disease, type A; Niemann-Pick disease, type B
GWAS		Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Neurological blood protein biomarker levels ( 31320639)	Copper levels ( 26025379)
Interacting Genes		6 interacting genes: ANXA4 ANXA7 ASAH1 BEX3 DUSP23 NR1H2	107 interacting genes: A1BG A2M ACTB ACTL6B ADAMTS10 ANGPT2 APC APLP1 ATP5F1B ATP6V1A ATXN3 BAG6 CCDC90B CCT7 CDK4 CELF3 CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE2 CPNE6 CRMP1 CSAD CTSB DDAH2 DMPK DOCK7 DVL1 DYNC1I1 EEF1A1 ERG28 EXT2 F13A1 FAF1 FBN3 FGB FLAD1 GAPDH GBP2 GDF9 GNB2 GNB5 HADHB HMGXB3 HOXD8 INPP5K INTS11 KLHL23 KMT2B LRIF1 MED31 MPPED1 MSH2 NGFR NMT2 NPRL2 OTUB1 PAAF1 PAX8 PDCD6 PDHB PKM PLD3 PRKACA PRKCA PRKCB PRKCG PRKG1 PSMB10 QARS1 RBBP4 RBM48 RPA1 RPL13 RPS2 S100A10 SDF4 SEMA5B SETDB1 SMPD1 SP110 SRC SRI SUMO3 TAF5L TIAM2 TLE1 TMEM108 TMSB4X TRMT2A TUBA1A TUBB2B TUBB3 UBE2D1 UCHL5 UNC119 USP4 VIM WDR18 WDR73 ZBTB16 ZNF135 ZNF431
Entrez ID		6609	310
HPRD ID		06353	01720
Ensembl ID		ENSG00000166311	ENSG00000138279
Uniprot IDs		E9LUE8 E9LUE9 P17405 Q59EN6 Q8IUN0	B2R657 P20073
PDB IDs		5I81 5I85 5I8R 5JG8
Enriched GO Terms of Interacting Partners?
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